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小儿先天性心脏病手术中高位脊髓麻醉对术后恢复的影响:一项回顾性倾向评分匹配研究

Impact of high spinal anesthesia in pediatric congenital heart surgery on postoperative recovery: a retrospective propensity score-matched study.

作者信息

Sivamurugan Aravinthasamy, Sondekoppam Rakesh, Rier Alex, Sadek Nada, Subramani Sudhakar, Rajagopal Srinivasan, Ranganath Yatish, Singhal Arun K, Hanada Satoshi

机构信息

Department of Anesthesia, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, USA.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.

出版信息

J Thorac Dis. 2024 Nov 30;16(11):7417-7426. doi: 10.21037/jtd-24-1157. Epub 2024 Nov 21.

Abstract

BACKGROUND

High spinal anesthesia (HSA) has been utilized in cardiac surgery; however, there is limited evidence on its impact on facilitating postoperative recovery. This study aimed to evaluate the impact of HSA in pediatric congenital heart surgery on postoperative recovery.

METHODS

A single center, propensity score-matched retrospective cohort study was designed using data from pediatric patients under 18 years old, who underwent congenital heart surgeries classified as Risk Adjustment for Congenital Heart Surgery-1 (RACHS-1) score 3 or less. The comparison was made between the HSA group, who received HSA in addition to general anesthesia (GA), and the GA group, who received GA alone. The primary outcome was the odds of patients being extubated in the operating room. Secondary outcomes included the odds of patients being extubated within 6 hours after intensive care unit (ICU) admission, as well as the length of stay (LOS) in the ICU and the hospital.

RESULTS

A total of 566 cases were eligible for this study, with 224 cases in the HSA group and 342 cases in the GA group. Propensity score-matching yielded a total of 197 pairs of patients. The rates of extubation in the operating room and within 6 hours after ICU admission were significantly higher in the HSA group compared to the GA group [65.5% 33.5%, odds ratio 3.82, 95% confidence interval (CI): 2.5 to 5.8, P<0.001; 82.7% 61.9%, odds ratio 2.95, 95% CI: 1.9 to 4.7, P<0.001, respectively]. The LOS in the ICU was significantly shorter in the HSA group while there was no significant difference in the LOS in the hospital between groups (5.1 8.0 days, P<0.001; 8.7 9.5 days, P<0.60, respectively).

CONCLUSIONS

The addition of HSA to GA in fast-track pediatric congenital heart surgery was associated with increased odds of extubation in the operating room, within 6 hours of ICU admission, and with a shorter LOS in the ICU. Future randomized controlled trials are needed to confirm these results.

摘要

背景

高位脊髓麻醉(HSA)已用于心脏手术;然而,关于其对促进术后恢复影响的证据有限。本研究旨在评估小儿先天性心脏病手术中HSA对术后恢复的影响。

方法

采用单中心、倾向评分匹配的回顾性队列研究,使用18岁以下接受先天性心脏病手术且先天性心脏病手术风险调整-1(RACHS-1)评分3分及以下的儿科患者的数据。比较接受全身麻醉(GA)加HSA的HSA组和仅接受GA的GA组。主要结局是患者在手术室拔管的几率。次要结局包括患者在重症监护病房(ICU)入院后6小时内拔管的几率,以及在ICU和医院的住院时间(LOS)。

结果

本研究共纳入566例患者,HSA组224例,GA组342例。倾向评分匹配后共得到197对患者。与GA组相比,HSA组在手术室及ICU入院后6小时内的拔管率显著更高[分别为65.5%对33.5%,比值比3.82,95%置信区间(CI):2.5至5.8,P<0.001;82.7%对61.9%,比值比2.95,95%CI:1.9至4.7,P<0.001]。HSA组在ICU的住院时间显著缩短,而两组在医院的住院时间无显著差异(分别为5.1对8.0天,P<0.001;8.7对9.5天,P<0.60)。

结论

在小儿先天性心脏病快速通道手术中,GA联合HSA与手术室拔管几率增加、ICU入院后6小时内拔管几率增加以及ICU住院时间缩短相关。未来需要进行随机对照试验来证实这些结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4d8/11635274/a4c3fedf2c37/jtd-16-11-7417-f1.jpg

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