Tariq Muhammad Ali, Malik Minhail Khalid, Khan Madiha, Majoka Zunaira Ahsan, Asrar Aeman
Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
Department of Medicine, Arnot Ogden Medical Center, Elmira, New York, USA.
Liver Int. 2025 Jan;45(1):e16212. doi: 10.1111/liv.16212.
Intrahepatic cholangiocarcinoma (ICC) is the second most frequent primary liver malignancy after hepatocellular carcinoma. Contemporary mortality trends due to ICC are largely unknown. We aim to examine the temporal trends of ICC-related deaths among older adults in the United States from 1999 to 2022.
We utilised the Centers for Disease Control and Prevention Wide-Ranging, Online Data for Epidemiologic Research (CDC WONDER) database, which provides information from death certificates of all US residents according to the International Classification of Diseases, Tenth Revision (ICD-10).
Between 1999 and 2022, there were 90 996 deaths attributed to ICC among individuals aged 65 and older. Overall, there is an increasing trend in ICC mortality; the total AAMR increased from 5.6 in 1999 to 14.3 in 2022 with an annual increase of 3.3%. Males had consistently higher AAMR than females across all years. For males, AAMR initially increased by 2.9% annually from 1999 to 2015, and since then, the rate has accelerated to a 3.9% annual increase. Conversely, females experienced a steady annual increase of 3.4% in AAMR from 1999 to 2022. When stratified by race, AAMR was highest among the Non-Hispanic (NH) Asian population, followed by Hispanic or Latino, NH Whites and NH Blacks. In brief, the AAMR has increased for all races; however, the NH Black population has experienced the greatest rise in AAMR during the study duration (APC: 4.0%; 95% CI, 3.5 to 4.8). Large metropolitan areas had a higher overall AAMR than small/medium metropolitan and non-metropolitan areas, though the rate of increase was comparable across all regions. States within the top 90th percentile of ICC-related deaths included Minnesota, Alaska, District of Columbia, Wisconsin, Massachusetts and Rhode Island.
Over the past two decades, there has been a consistent rise in mortality rates associated with intrahepatic cholangiocarcinoma in the United States. This upward trajectory underscores the imperative for additional research aimed at comprehending and delineating the underlying risk factors driving this increase.
肝内胆管癌（ICC）是仅次于肝细胞癌的第二常见原发性肝癌。目前，ICC导致的死亡率趋势尚不清楚。我们旨在研究1999年至2022年美国老年人中与ICC相关的死亡的时间趋势。
我们使用了疾病控制和预防中心的广泛在线流行病学研究数据（CDC WONDER）数据库，该数据库根据国际疾病分类第十版（ICD-10）提供所有美国居民死亡证明的信息。
1999年至2022年期间，65岁及以上人群中有90996例死亡归因于ICC。总体而言，ICC死亡率呈上升趋势；年龄标准化死亡率（AAMR）从1999年的5.6上升至2022年的14.3，年增长率为3.3%。在所有年份中，男性的AAMR始终高于女性。对于男性，1999年至2015年AAMR最初每年增长2.9%，从那时起，增长率加速至每年3.9%。相反，1999年至2022年女性的AAMR每年稳定增长3.4%。按种族分层时，非西班牙裔（NH）亚洲人群的AAMR最高，其次是西班牙裔或拉丁裔、NH白人及NH黑人。简而言之，所有种族的AAMR均有所上升；然而，在研究期间NH黑人人群的AAMR上升幅度最大（年龄别百分比变化率：4.0%；95%置信区间，3.5至4.8）。大城市地区的总体AAMR高于中小城市和非城市地区，尽管所有地区的增长率相当。ICC相关死亡人数处于第90百分位以上的州包括明尼苏达州、阿拉斯加州、哥伦比亚特区、威斯康星州、马萨诸塞州和罗德岛州。
在过去二十年中，美国肝内胆管癌相关死亡率持续上升。这一上升趋势凸显了开展更多研究以理解和确定导致这一增长的潜在风险因素的紧迫性。
