Weng Pei-Chun, Zhang Jun-Fu, Kuo Chang-Fu, Huang Yu-Huei
Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
Center for Artificial Intelligence in Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan, Taiwan.
J Dtsch Dermatol Ges. 2025 Jan;23(1):54-63. doi: 10.1111/ddg.15555. Epub 2024 Dec 16.
Studies have identified increased risks of pregnancy complications in expectant mothers with atopic dermatitis (AD). However, the associations between maternal AD and adverse pregnancy or offspring outcomes in Asians remain unexplored. Our aim was to investigate the relationship between maternal AD and adverse pregnancy and offspring outcomes in Taiwan.
This retrospective cohort study collected data from Taiwan's National Health Insurance Research Database and the Taiwan Maternal and Child Health Database between 2003 and 2019. We recruited 15,495 AD mothers and 77,475 non-AD mothers, as well as 19,173 children born to AD mothers and 95,865 children born to non-AD mothers, using propensity score matching. Pregnancy and offspring outcomes were compared in the maternal and offspring cohorts, respectively.
AD mothers had higher risks of threatened abortion, preeclampsia/eclampsia, premature rupture of membranes, threatened preterm labor, fetal growth restriction, antepartum hemorrhage, postpartum hemorrhage, anemia, surgical complications, infections, pulmonary events, and renal events, with adjusted hazard ratios of 1.09-1.71. Children born to AD mothers had increased risks of AD, allergic rhinitis, asthma, alopecia areata, and attention deficit hyperactivity disorder, with adjusted hazard ratios of 1.05-2.29.
There is a significant association between maternal AD and adverse pregnancy and offspring outcomes in Taiwan.
研究已确定患有特应性皮炎（AD）的准妈妈出现妊娠并发症的风险增加。然而，亚洲人群中母亲患AD与不良妊娠或后代结局之间的关联仍未得到探索。我们的目的是调查台湾地区母亲患AD与不良妊娠及后代结局之间的关系。
这项回顾性队列研究收集了2003年至2019年间台湾地区国民健康保险研究数据库和台湾妇幼健康数据库的数据。我们采用倾向得分匹配法招募了15495名患AD的母亲和77475名未患AD的母亲，以及19173名患AD母亲所生的孩子和95865名未患AD母亲所生的孩子。分别在母亲队列和后代队列中比较妊娠和后代结局。
患AD的母亲出现先兆流产、子痫前期/子痫、胎膜早破、先兆早产、胎儿生长受限、产前出血、产后出血、贫血、手术并发症、感染、肺部疾病和肾脏疾病的风险更高，调整后的风险比为1.09至1.71。患AD母亲所生的孩子患AD、过敏性鼻炎、哮喘、斑秃和注意力缺陷多动障碍的风险增加，调整后的风险比为1.05至2.29。
在台湾地区，母亲患AD与不良妊娠及后代结局之间存在显著关联。
