Wilson F J, Hiller F C, Wilson J D, Bone R C
J Appl Physiol (1985). 1985 Jan;58(1):223-9. doi: 10.1152/jappl.1985.58.1.223.
Theoretical models of particle deposition in the respiratory tract predict high fractional deposition for particles of less than 0.1 micron, but there are few confirming experimental data for those predictions. We have measured the deposition fraction of a nonhygroscopic aerosol in the human respiratory tract. The aerosol had a count mean diameter of 0.044 micron SD of 1.93, as measured with an electrical aerosol analyzer, and was produced from a 0.01% solution of bis(2-ethylhexyl) sebacate using a condensation generator. Subjects inhaled the aerosol using a controlled respiratory pattern of 1 liter tidal volume, 12/min. Deposition was calculated as the difference in concentration between inhaled and exhaled aerosol of five size fractions corrected for system deposition and dead-space constants. Three deposition studies were done on each of five normal male volunteers. Means (+/- SE) for the five size fractions were 0.024 micron, 0.71 +/- 0.06; 0.043 micron, 0.62 +/- 0.06; 0.075 micron, 0.53 +/- 0.05; 0.13 micron, 0.44 +/- 0.04; and 0.24 micron, 0.37 +/- 0.06. These data demonstrate that deposition of inhaled particles in the 0.024- to 0.24-micron size range is high and increases with decreasing size. These observations agree with and validate predictions of mathematical models.
呼吸道中颗粒沉积的理论模型预测，直径小于0.1微米的颗粒具有较高的分数沉积率，但几乎没有实验数据能证实这些预测。我们测量了一种非吸湿性气溶胶在人体呼吸道中的沉积分数。用电子气溶胶分析仪测得，该气溶胶的计数平均直径为0.044微米，标准差为1.93，它由癸二酸二（2-乙基己基）酯的0.01%溶液通过冷凝发生器产生。受试者以1升潮气量、每分钟12次的受控呼吸模式吸入气溶胶。沉积量通过吸入和呼出的五个粒径分数的气溶胶浓度差来计算，并对系统沉积和死腔常数进行校正。对五名正常男性志愿者每人进行了三项沉积研究。五个粒径分数的平均值（±标准误）分别为：0.024微米，0.71±0.06；0.043微米，0.62±0.06；0.075微米，0.53±0.05；0.13微米，0.44±0.04；0.24微米，0.37±0.06。这些数据表明，0.024至0.24微米粒径范围内吸入颗粒的沉积率很高，且随粒径减小而增加。这些观察结果与数学模型的预测相符并验证了该预测。
