检测认知正常以预测阿尔茨海默病。

Testing cognitive normal for Alzheimer's disease prediction.

作者信息

Meng Jie, Lei Peng

机构信息

Department of Geriatrics and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Department of Neurology and State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

出版信息

J Neurochem. 2025 Jan;169(1):e16272. doi: 10.1111/jnc.16272.

DOI:10.1111/jnc.16272

PMID:39680494

Abstract

One standing challenge for Alzheimer's disease (AD) research is early diagnosis, which provides a time window for early intervention. Sharmin et al recently reported a positive association between plasma ptau181 and plasma metabolites, medium- and long-chain acylcarnitines (ACs) in both cognitively normal (CN) Aβ- and CN Aβ+ older adults, suggesting a link between initial Aβ pathology and acylcarnitine-mediated energy metabolism pathways. Consistently, ACs could classify PET-Aβ status in elderly individuals. This study has provided further clues for early biomarker searching for AD, linking metabolic pathways with AD pathogenesis.

摘要

阿尔茨海默病（AD）研究面临的一个长期挑战是早期诊断，它为早期干预提供了一个时间窗口。沙尔敏等人最近报告称，在认知正常（CN）的Aβ-和CN Aβ+老年人中，血浆ptau181与血浆代谢物、中长链酰基肉碱（ACs）之间存在正相关，这表明初始Aβ病理与酰基肉碱介导的能量代谢途径之间存在联系。同样，ACs可以对老年人的PET-Aβ状态进行分类。这项研究为寻找AD的早期生物标志物提供了进一步线索，将代谢途径与AD发病机制联系起来。