Tang Jason Y, Chen Trevor B, Kouznetsova Valentina L, Tsigelny Igor F
Tufts School of Arts and Sciences, Tufts University, Medford, Massachusetts.
MAP Program.
J Infect Dis. 2025 Feb 20;231(2):298-306. doi: 10.1093/infdis/jiae626.
Anelloviruses are among the most prevalent viruses within the human virome, detected in >90% of healthy individuals. Despite their ubiquity, the role of anelloviruses in human health remains elusive. This review examines the potential associations of the anelloviruses torque teno virus (TTV), torque teno midi virus (TTMDV), and torque teno mini virus (TTMV) with various cancers, highlighting the mixed conclusions from current epidemiological studies. Anelloviruses may modulate cancer development through abnormal gene fusion, immune response, and Toll-like receptor 9 (TLR9) activation. On the other hand, anelloviruses might suppress tumor formation through TTV-derived apoptosis-inducing protein (TAIP) and NF-κB signaling inhibition. The high prevalence of anelloviruses in cancer patients could also be attributed to their immunocompromised status rather than a direct causative role of the viruses. This review underscores the need for more comprehensive studies, including in vitro and in vivo experiments, to clarify the role of anelloviruses in cancer development and progression.
环曲病毒是人类病毒组中最普遍的病毒之一，在90%以上的健康个体中都能检测到。尽管它们无处不在，但环曲病毒在人类健康中的作用仍不明确。本综述探讨了环曲病毒中的细小病毒B19（TTV）、中细小病毒（TTMDV）和微小细小病毒（TTMV）与各种癌症的潜在关联，强调了当前流行病学研究得出的混合结论。环曲病毒可能通过异常基因融合、免疫反应和Toll样受体9（TLR9）激活来调节癌症发展。另一方面，环曲病毒可能通过TTV衍生的凋亡诱导蛋白（TAIP）和NF-κB信号抑制来抑制肿瘤形成。癌症患者中环曲病毒的高流行率也可能归因于他们的免疫功能低下状态，而不是病毒的直接致病作用。本综述强调需要进行更全面的研究，包括体外和体内实验，以阐明环曲病毒在癌症发展和进展中的作用。
