Lepage Tristan M, Nzune-Toche Narcisse, Nkwengoua Lucie A, Nana-Djeunga Hugues C, Pion Sebastien D S, Kamgno Joseph, Boullé Charlotte, Campillo Jérémy T, Boussinesq Michel, Tayou Claude T, Chesnais Cédric B
Department of Infectious and Tropical Diseases, Montpellier University Teaching Hospital, Montpellier, France.
TransVIHMI, Montpellier University, INSERM Unité 1175, Institut de Recherche pour le Développement (IRD), Montpellier, France.
PLoS Negl Trop Dis. 2024 Dec 16;18(12):e0012491. doi: 10.1371/journal.pntd.0012491. eCollection 2024 Dec.
We assessed the impact of loiasis and its treatment with ivermectin on hemostasis and inflammation in 38 adults in Cameroon. Participants were divided into four balanced groups based on their Loa loa microfilarial densities. At baseline, eosinophils and platelets increased with microfilarial densities (p<0.001 and p = 0.044, respectively). At day 4 following ivermectin administration, median eosinophils rose from 171/μL to 1,095/μL (p<0.001) and median D-dimers increased from 582 ng/mL to 745 ng/mL (p = 0.024) with a median relative variation of +34.7%. C-reactive protein, fibrinogen, and alpha-1-globulin also increased significantly after treatment. Ivermectin treatment appeared to induce inflammation, coagulation activation and fibrinolysis.
我们评估了盘尾丝虫病及其用伊维菌素治疗对喀麦隆38名成年人止血和炎症的影响。参与者根据其罗阿丝虫微丝蚴密度分为四个平衡组。在基线时，嗜酸性粒细胞和血小板随微丝蚴密度增加（分别为p<0.001和p = 0.044）。在给予伊维菌素后的第4天，嗜酸性粒细胞中位数从171/μL升至1,095/μL（p<0.001），D-二聚体中位数从582 ng/mL增至745 ng/mL（p = 0.024），中位数相对变化为+34.7%。治疗后C反应蛋白、纤维蛋白原和α-1球蛋白也显著增加。伊维菌素治疗似乎会诱发炎症、凝血激活和纤维蛋白溶解。
