Raju Soniya, Kularatna Nihal, Wilson Marcus, Steyn-Ross D Alistair
Te Aka Mātuatua School of Science, University of Waikato, New Zealand.
Te Kura Mata-Ao School of Engineering, University of Waikato, New Zealand.
Biomed Phys Eng Express. 2024 Dec 26;11(1). doi: 10.1088/2057-1976/ad9f6b.
In transcranial magnetic stimulation (TMS), pulsed magnetic fields are applied to the brain, typically requiring high-power stimulators with high voltages and low series impedance. TMS pulse generators for small animal coils, are underexplored, with limited dedicated circuits and simulation models. Here, we present a new design for a high-power TMS pulse generator for small animals, utilizing a pre-charged supercapacitor that is sufficient to produce repeated pulses for TMS applications without the need for recharging. This approach eliminates the need for expensive high-voltage components and a high-voltage power supply. In this paper, we detail the design approach and basic block diagrams of a supercapacitor (SC) based TMS pulse generator, along with its experimental results. The findings indicate that the new circuit enables a complete test using just a single charge of an SC module. The proposed circuit functions as a versatile pulse-shaping device, where the MOSFET is treated as a dynamically varying resistor element rather than a traditional switch; allowing pulse parameter variations. We analyze a novel circuit for generating and controlling TMS pulses in small animal coils, and demonstrate its effectiveness through experimental results.
在经颅磁刺激（TMS）中，脉冲磁场被施加到大脑，这通常需要具有高电压和低串联阻抗的高功率刺激器。用于小动物线圈的TMS脉冲发生器尚未得到充分研究，专用电路和仿真模型有限。在此，我们展示了一种用于小动物的高功率TMS脉冲发生器的新设计，它利用预充电的超级电容器，该电容器足以产生用于TMS应用的重复脉冲而无需充电。这种方法无需昂贵的高压组件和高压电源。在本文中，我们详细介绍了基于超级电容器（SC）的TMS脉冲发生器的设计方法和基本框图，以及其实验结果。研究结果表明，新电路仅使用一次SC模块充电就能完成测试。所提出的电路用作通用的脉冲整形装置，其中MOSFET被视为动态变化的电阻元件而非传统开关；允许脉冲参数变化。我们分析了一种用于在小动物线圈中产生和控制TMS脉冲的新型电路，并通过实验结果证明了其有效性。
