Zhang Yichen, Jiang Yong'An, Fan Hengyi, Yuan Raorao, Cai Jianhui, Zhong Bo, Qin Qian, Zhang Zile, Zhang Yan, Cheng Shiqi
Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, PR China; Nanchang University, Nanchang, Jiangxi 330006, PR China.
Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, PR China.
Behav Brain Res. 2025 Mar 5;480:115400. doi: 10.1016/j.bbr.2024.115400. Epub 2024 Dec 15.
An epidemiological association between anxiety and stroke is well-established; however, the role of shared genetic factors remain unclear. This study aimed to investigate the shared genetic architecture between anxiety and stroke.
Using public genome-wide association study (GWAS) summary statistics of anxiety and stroke, we performed linkage disequilibrium score regression and super genetic covariance analyzer for global and local genetic correlation studies. Risk single nucleotide polymorphisms (SNPs) were identified through genome-wide association meta-analysis, multi-trait analysis of GWAS and PLINK, followed by functional mapping and annotation. Additionally, we conducted transcriptome-wide association studies to explore the relationship between genes and associated disease risk.
Our analysis revealed a significant genome-wide genetic correlation between anxiety and stroke. We also identified one previously unreported significant SNP (rs62099231), one risk loci, as well as identified three shared risk genes for anxiety and stroke (WDR6, CCDC71, NCKIPSD).
Our study demonstrated a shared genetic structure between anxiety and stroke, enhancing our understanding of their pathogenesis and highlighting potential therapeutic targets.
焦虑与中风之间的流行病学关联已得到充分证实；然而，共享遗传因素的作用仍不清楚。本研究旨在调查焦虑与中风之间共享的遗传结构。
利用焦虑和中风的公开全基因组关联研究（GWAS）汇总统计数据，我们进行了连锁不平衡评分回归和超级遗传协方差分析，以进行全局和局部遗传相关性研究。通过全基因组关联荟萃分析、GWAS多性状分析和PLINK鉴定风险单核苷酸多态性（SNP），随后进行功能定位和注释。此外，我们进行了全转录组关联研究，以探索基因与相关疾病风险之间的关系。
我们的分析揭示了焦虑与中风之间全基因组显著的遗传相关性。我们还鉴定出一个先前未报告的显著SNP（rs62099231）、一个风险位点，并确定了焦虑和中风的三个共享风险基因（WDR6、CCDC71、NCKIPSD）。
我们的研究证明了焦虑与中风之间存在共享的遗传结构，增进了我们对其发病机制的理解，并突出了潜在的治疗靶点。
