Shao Yan, Guo Yupeng, Chen Yun, Zou Guangyuan, Chen Jie, Gao Xuejiao, Lu Panpan, Tong Yujie, Li Yuezhen, Yao Ping, Liu Jiayi, Zhou Shuqin, Xu Jing, Gao Jia-Hong, Zou Qihong, Sun Hongqiang
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Peking University, Beijing, PR China.
Beijing City Key Lab for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University, Beijing, PR China; Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, PR China.
Neuroimage. 2025 Jan;305:120976. doi: 10.1016/j.neuroimage.2024.120976. Epub 2024 Dec 15.
The association between spindle metrics and sleep architecture differs during N2 vs. N3 sleep, the underlying neural mechanism is not clearly illustrated. Here, we tested the discrepancy in spindle-related brain activation between N2 and N3 within healthy college students (dataset 1: n = 27, 59 % females, median age 23 years), using simultaneous electroencephalography-functional magnetic resonance imaging (EEG-fMRI). To assess the replicability of the finding, we repeated the analysis among normal adults (independent dataset 2: n = 30, 50 % females, median age 32 years). The finding from dataset 1 indicated significantly increased blood-oxygen level-dependent signal in the right middle temporal gyrus during N2 compared with N3, which was well replicated in dataset 2. Furthermore, correlation analysis was performed to explore the association between this spindle-related brain activation and N2, N3 sleep duration during EEG-fMRI. We conducted the correlation analysis in N2 and N3, respectively. The negative association between spindle-related brain activation in the right middle temporal gyrus and sleep duration was only observed in N2. Our findings emphasize the unique role of spindle-related brain activation in the right middle temporal gyrus during N2 in shortening N2 sleep duration.
纺锤波指标与睡眠结构之间的关联在N2睡眠和N3睡眠期间有所不同，但其潜在的神经机制尚未得到清晰阐释。在此，我们利用同步脑电图-功能磁共振成像（EEG-fMRI），测试了健康大学生（数据集1：n = 27，59%为女性，年龄中位数23岁）在N2和N3睡眠期间与纺锤波相关的大脑激活差异。为评估该发现的可重复性，我们在正常成年人中重复了分析（独立数据集2：n = 30，50%为女性，年龄中位数32岁）。数据集1的结果表明，与N3睡眠相比，N2睡眠期间右侧颞中回的血氧水平依赖信号显著增加，这在数据集2中得到了很好的重复。此外，我们进行了相关性分析，以探讨这种与纺锤波相关的大脑激活与EEG-fMRI期间N2、N3睡眠时间之间的关联。我们分别在N2和N3睡眠中进行了相关性分析。仅在N2睡眠中观察到右侧颞中回与纺锤波相关的大脑激活与睡眠时间之间存在负相关。我们的研究结果强调了N2睡眠期间右侧颞中回与纺锤波相关的大脑激活在缩短N2睡眠时间方面的独特作用。
