Dernevik L, Arvidsson S, William-Olsson G
J Cardiovasc Surg (Torino). 1985 Jan-Feb;26(1):32-5.
Eight dogs were cannulated for left heart bypass. Conventional roller pumps were used for bypass with one of the pump console modified to deliver pulsatile bypass. The experiments were performed at normothermia. Each dog was used as its own control. For measurement of cerebral blood flow (CBF) Xe133 was injected into vertebral artery and the gamma activity elimination over the skull was registered. In addition blood samples were withdrawn from the axillary artery and the sagittal sinus for measurement of blood gases. The CBF to the gray matter of the brain was significantly higher during the periods with pulsatile perfusion (P less than 0.01). This was probably due to decreased total cerebral vascular resistance (P less than 0.001). Mean aortic pressure also decreased when the mode of perfusion was changed from non pulsatile to pulsatile (P less than 0.05), indicating a general decrease of the peripheral vascular resistance. A good correlation was noted between the arteriovenous oxygen saturation difference (AV-O2 diff) across the brain and the CBF (R = -0.77, P less than 0.01).
八只狗被插管用于左心旁路手术。使用传统滚压泵进行旁路循环，其中一台泵控制台经过改装以提供搏动性旁路循环。实验在正常体温下进行。每只狗都作为自身对照。为测量脑血流量（CBF），将Xe133注入椎动脉，并记录颅骨上的γ活性消除情况。此外，从腋动脉和矢状窦采集血样以测量血气。在搏动性灌注期间，大脑灰质的脑血流量显著更高（P<0.01）。这可能是由于总脑血管阻力降低（P<0.001）。当灌注模式从非搏动性变为搏动性时，平均主动脉压也降低（P<0.05），表明外周血管阻力普遍降低。大脑动静脉血氧饱和度差（AV-O2 diff）与脑血流量之间存在良好的相关性（R = -0.77，P<0.01）。
