Rizzo Stefania, Gasparri Maria Luisa, Manganaro Lucia, Del Grande Filippo, Papadia Andrea, Petrella Francesco
Clinica di Radiologia EOC, Istituto Imaging della Svizzera Italiana (IIMSI), Via Tesserete 46, 6900 Lugano, Switzerland.
Facoltà di Scienze Biomediche, Università della Svizzera Italiana (USI), Via Giuseppe Buffi 13, 6900 Lugano, Switzerland.
Cancers (Basel). 2024 Nov 27;16(23):3985. doi: 10.3390/cancers16233985.
Ovarian cancer typically presents at advanced stages, with prognosis heavily influenced by the presence of residual disease following cytoreductive surgery. The role of resecting enlarged extra-abdominal lymph nodes during cytoreductive procedures remains contentious. These enlarged lymph nodes are commonly identified through high-resolution imaging techniques such as ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT). A comprehensive understanding of the relevant anatomy, imaging modalities, and surgical techniques for addressing lymphadenopathy in regions such as the supraclavicular fossa, axillae, mediastinum, and pericardiophrenic fat is crucial in determining the feasibility of surgical intervention. An appropriate evaluation of these factors is essential to optimize debulking, which is recognized as the most significant prognostic determinant in patients with ovarian cancer. This review underscores the importance of multidisciplinary approaches in managing advanced ovarian cancer with extra-abdominal lymph node involvement to enhance patient outcomes.
卵巢癌通常在晚期出现，其预后在很大程度上受细胞减灭术后残留病灶的影响。在细胞减灭术中切除肿大的腹外淋巴结的作用仍存在争议。这些肿大的淋巴结通常通过高分辨率成像技术来识别，如超声（US）、计算机断层扫描（CT）、磁共振成像（MRI）和正电子发射断层扫描 - 计算机断层扫描（PET-CT）。全面了解相关解剖结构、成像方式以及处理锁骨上窝、腋窝、纵隔和心包膈脂肪等区域淋巴结病变的手术技术，对于确定手术干预的可行性至关重要。对这些因素进行适当评估对于优化肿瘤细胞减灭至关重要，而肿瘤细胞减灭被认为是卵巢癌患者最重要的预后决定因素。这篇综述强调了多学科方法在治疗伴有腹外淋巴结受累的晚期卵巢癌以提高患者预后方面的重要性。
