由H3K27me3介导，通过调控……的转录抑制猪卵泡发育。（原文中“by regulating the transcription of.”后面缺少具体内容）

Mediated by H3K27me3 Inhibits Porcine Follicular Development by Regulating the Transcription of .

作者信息

Zhou Zhi, Lv Yuanyuan, Li Liying, Yuan Xiaolong, Zhou Xiaofeng, Li Jiaqi

机构信息

State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.

出版信息

Animals (Basel). 2024 Dec 5;14(23):3514. doi: 10.3390/ani14233514.

DOI:10.3390/ani14233514

PMID:39682478

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11640192/

Abstract

It is well known that the function of granulosa cells (GCs) is closely related to follicular development, and and histone methylation have been implicated in follicular development. However, the specific mechanisms by which and histone methylation regulate follicular development are still largely unknown. To explore the specific mechanism of in regulating follicular development, in this study, we showed that the expression of in immature ovaries and small follicles was significantly higher than in mature ovaries and large follicles of sows, respectively. was found to inhibit the secretion of testosterone and proliferation of porcine GCs and promote the secretion of progesterone and apoptosis of porcine GCs. Furthermore, H3K27me3, as a transcriptional inhibitor, can inhibit the transcription of . could promote the transcription of , and was found to inhibit the proliferation and facilitate the ferroptosis of porcine GCs. Collectively, our results revealed that the H3K27me3-- pathway might participate in follicular development, and these findings could provide potential targets for improving follicular development in sows.

摘要

众所周知，颗粒细胞（GCs）的功能与卵泡发育密切相关，并且[此处原文缺失关键物质]和组蛋白甲基化与卵泡发育有关。然而，[此处原文缺失关键物质]和组蛋白甲基化调节卵泡发育的具体机制仍 largely未知。为了探索[此处原文缺失关键物质]调节卵泡发育的具体机制，在本研究中，我们发现[此处原文缺失关键物质]在未成熟卵巢和小卵泡中的表达分别显著高于母猪的成熟卵巢和大卵泡。[此处原文缺失关键物质]被发现抑制睾酮分泌和猪颗粒细胞增殖，并促进孕酮分泌和猪颗粒细胞凋亡。此外，H3K27me3作为一种转录抑制剂，可以抑制[此处原文缺失关键物质]的转录。[此处原文缺失关键物质]可以促进[此处原文缺失关键物质]的转录，并且[此处原文缺失关键物质]被发现抑制猪颗粒细胞的增殖并促进其铁死亡。总体而言，我们的结果表明H3K27me3-[此处原文缺失关键物质]途径可能参与卵泡发育，这些发现可为改善母猪卵泡发育提供潜在靶点。