Bellomo Claudia, Furone Francesca, Rotondo Roberta, Ciscognetti Ilaria, Carpinelli Martina, Nicoletti Martina, D'Aniello Genoveffa, Sepe Leandra, Barone Maria Vittoria, Nanayakkara Merlin
Department of Translational Medical Science, Section of Pediatrics, University Federico II, Via S. Pansini 5, 80131 Naples, Italy.
Department of Medicine and Surgery, University of Parma, 43121 Parma, Italy.
Cells. 2024 Nov 29;13(23):1981. doi: 10.3390/cells13231981.
Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous cellular processes, such as cell growth, inflammation, differentiation, immune-mediated responses and oncogenic transformation. The aim of this review is to review the literature concerning the role of several PTPs-PTPN22, PTPN2, PTPN6, PTPN11, PTPσ, DUSP2, DUSP6 and PTPRK-at the level of the intestinal mucosa in inflammatory bowel disease (IBD), celiac disease (CeD) and type 1 diabetes (T1D) in both in vitro and in vivo models. The results revealed shared features, at the level of the intestinal mucosa, between these diseases characterized by alterations of different biological processes, such as proliferation, autoimmunity, cell death, autophagy and inflammation. PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs.
蛋白酪氨酸磷酸酶（PTPs）是一类对众多细胞过程至关重要的酶，这些过程包括细胞生长、炎症、分化、免疫介导反应和致癌转化。本综述的目的是回顾有关几种PTPs——PTPN22、PTPN2、PTPN6、PTPN11、PTPσ、DUSP2、DUSP6和PTPRK——在炎症性肠病（IBD）、乳糜泻（CeD）和1型糖尿病（T1D）的体外和体内模型中在肠黏膜水平所起作用的文献。结果揭示了这些以不同生物学过程改变（如增殖、自身免疫、细胞死亡、自噬和炎症）为特征的疾病在肠黏膜水平上的共同特征。目前正在积极研究PTPs以开发新药。考虑到类器官作为以个性化方式测试新药的模型的可用性，这些蛋白质很可能很快会成为有用药物的靶点。
