Spinelli Sara, Marino Angela, Morabito Rossana, Remigante Alessia
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
Cells. 2024 Dec 7;13(23):2026. doi: 10.3390/cells13232026.
Red blood cells (RBCs) are highly specialized cells with a limited metabolic repertoire. However, it has been demonstrated that metabolic processes are affected by the production of reactive oxygen species (ROS), and critical enzymes allied to metabolic pathways can be impaired by redox reactions. Thus, oxidative stress-induced alternations in the metabolic pathways can contribute to cell dysfunction of human RBCs. Herein, we aim to provide an overview on the metabolic pathways of human RBCs, focusing on their pathophysiological relevance and their regulation in oxidative stress-related conditions.
红细胞（RBCs）是高度特化的细胞，其代谢功能有限。然而，已经证明代谢过程会受到活性氧（ROS）产生的影响，并且与代谢途径相关的关键酶可能会因氧化还原反应而受损。因此，氧化应激诱导的代谢途径改变可能导致人类红细胞的细胞功能障碍。在此，我们旨在概述人类红细胞的代谢途径，重点关注其病理生理相关性以及在氧化应激相关条件下的调节。
