Ricottini Lucilla, Basciani Sabrina, Spizzichini Maria Letizia, de Mattia Domenico, Coniglio-Iannuzzi Delle Noci Manuela, Sorrentino Sasha, Nordio Maurizio
Sinergheia Clinical Center, 00192 Rome, Italy.
Department of Experimental Medicine, University "Sapienza", 00161 Rome, Italy.
Nutrients. 2024 Nov 21;16(23):3977. doi: 10.3390/nu16233977.
The aim of the present study was to evaluate the effectiveness and safety of a nutraceutical combination given to insulin-resistant overweight patients with altered lipid profiles. To this end, an observational study was designed in which 74 individuals (50 females and 24 males) underwent an observational period of 3 months.
During this time, a specific nutraceutical combination containing myo-inositol, glycine, , α-lipoic acid, phlorizin, zinc, vitamin B, and chromium picolinate was administered. Patients were asked not to modify their lifestyles so that no variable that might interfere with results was introduced.
After the 3-month period, the obtained data revealed that insulin levels significantly decreased with respect to the baseline, while glucose levels exhibited a trend towards lower concentrations, which was not significant. In addition, HOMA-IR index, body weight, BMI, and abdominal circumference values all decreased significantly. Regarding lipid profiles, the data obtained before and after the 3-month period showed statistically significant decreases in concentrations of total cholesterol, LDL cholesterol, and triglyceride, as well as a small but statistically significant concomitant increase in HDL cholesterol.
Thus, on the basis of these data, it may be stated that the specific nutraceutical combination used in the present study significantly ameliorated a number of metabolic parameters without measurable side effects. The efficacy and safety of the product were, therefore, confirmed in our group of patients.
本研究的目的是评估给予胰岛素抵抗且血脂异常的超重患者一种营养保健品组合的有效性和安全性。为此，设计了一项观察性研究，74名个体（50名女性和24名男性）接受了为期3个月的观察期。
在此期间，给予一种特定的营养保健品组合，其中含有肌醇、甘氨酸、α-硫辛酸、根皮苷、锌、维生素B和吡啶甲酸铬。要求患者不要改变他们的生活方式，以免引入可能干扰结果的变量。
3个月后，获得的数据显示胰岛素水平相对于基线显著下降，而血糖水平呈现出浓度降低的趋势，但不显著。此外，HOMA-IR指数、体重、BMI和腹围值均显著下降。关于血脂谱，3个月前后获得的数据显示总胆固醇、低密度脂蛋白胆固醇和甘油三酯浓度在统计学上显著降低，同时高密度脂蛋白胆固醇有小幅但在统计学上显著的升高。
因此，基于这些数据，可以说本研究中使用的特定营养保健品组合显著改善了一些代谢参数，且无明显副作用。因此，该产品在我们的患者群体中的有效性和安全性得到了证实。
