Basiri Raedeh, Cheskin Lawrence J
Department of Nutrition and Food Studies, George Mason University, Fairfax, VA 22030, USA.
Institute for Biohealth Innovation, George Mason University, Fairfax, VA 22030, USA.
Nutrients. 2024 Nov 22;16(23):4005. doi: 10.3390/nu16234005.
BACKGROUND/OBJECTIVES: prediabetes is a significant risk factor for the development of type 2 diabetes, cardiovascular diseases, chronic kidney disease, and other complications. Early diagnosis of prediabetes, coupled with education on lifestyle changes that support blood glucose management, are crucial for the prevention or delay of type 2 diabetes and related complications. This study aimed to evaluate the impact of incorporating real-time feedback from continuous glucose monitoring (CGM) into individualized nutrition therapy (INT) on blood glucose control in individuals with prediabetes who are overweight or obese.
participants (mean age ± SD: 55 ± 6 years; BMI: 31.1 ± 4.1 kg/m²) were randomly assigned to either the treatment group ( = 15) or the control group ( = 15). Both groups received INT and CGM, but the control group was blinded to the CGM data until the end of this study. Participants were followed for 30 days and visited the lab every 10 days for CGM replacement, study measurements, and dietary consultations.
the treatment group showed a significant increase in the percentage of time spent in the target blood glucose range ( = 0.02) and a significant decrease in the mean blood glucose concentration ( < 0.05), glucose management indicator ( = 0.02), percent coefficient of variation for blood glucose ( = 0.01), and percent time spent in the high or very high blood glucose ranges ( = 0.04). These changes were not statistically significant for the control group.
adding CGM feedback to INT resulted in better management of blood glucose levels in overweight or obese individuals with prediabetes.
背景/目的：糖尿病前期是2型糖尿病、心血管疾病、慢性肾脏病及其他并发症发生的重要危险因素。早期诊断糖尿病前期，并开展有助于血糖管理的生活方式改变教育，对于预防或延缓2型糖尿病及相关并发症至关重要。本研究旨在评估将持续葡萄糖监测（CGM）的实时反馈纳入个体化营养治疗（INT）对超重或肥胖的糖尿病前期个体血糖控制的影响。
参与者（平均年龄±标准差：55±6岁；体重指数：31.1±4.1kg/m²）被随机分为治疗组（n = 15）或对照组（n = 15）。两组均接受INT和CGM，但对照组在本研究结束前对CGM数据不知情。参与者随访30天，每10天到实验室进行CGM更换、研究测量和饮食咨询。
治疗组在目标血糖范围内的时间百分比显著增加（P = 0.02），平均血糖浓度显著降低（P < 0.05），血糖管理指标（P = 0.02）、血糖变异系数百分比（P = 0.01）以及在高或非常高血糖范围内的时间百分比（P = 0.04）均显著降低。对照组的这些变化无统计学意义。
在INT中加入CGM反馈可使超重或肥胖的糖尿病前期个体的血糖水平得到更好的管理。
