Grosu Iustina, Constantinescu Alexandru, Balta Mihaela Daniela, Băjenaru Ovidiu, Nuța Cătălina, Pavel Christopher, Sandru Vasile, Munteanu Mihai, Andronic Octavian
Endocrinology Department, "Elias" University Emergency Hospital, 011461 Bucharest, Romania.
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Nutrients. 2024 Nov 27;16(23):4085. doi: 10.3390/nu16234085.
From the observation of a negative relationship between UV-B exposure and cancer rates, we hypothesized that vitamin D (VD) may play a protective role in oncogenesis. Moreover, repurposing a well-known and relatively safe drug for conditions with dismal prospects, such as pancreatic ductal adenocarcinoma (PDAC), is a tempting idea. Thus, we aimed to summarize the current knowledge regarding the role of VD in the prevention and treatment of PDAC.
We conducted a systematic review of VD and PDAC using Medline-indexed studies accessed through PubMed as the primary data source. This study aimed to identify articles focusing on the role of VD as a risk and prognostic factor for PDAC, mechanistic studies evaluating the effects of VD or vitamin D analogs (VDAs) in PDAC models, and clinical trials on VDAs in PDAC. After the screening, 97 studies were included in the final manuscript.
Even though the results from epidemiologic studies were contradictory, basic research has demonstrated that VD can act on PDAC cells either directly, inhibiting proliferation, apoptosis, EMT, migration, invasion, and stemness, or indirectly, through stromal remodeling. A better understanding of the consequences of VD-induced tumor-stroma cross-talk alterations is needed to determine whether VD/VDAs can be used to our own advantage in the treatment of PDAC.
通过观察紫外线B暴露与癌症发病率之间的负相关关系，我们推测维生素D（VD）可能在肿瘤发生过程中发挥保护作用。此外，将一种知名且相对安全的药物重新用于治疗前景不佳的疾病，如胰腺导管腺癌（PDAC），是一个很有吸引力的想法。因此，我们旨在总结目前关于VD在PDAC预防和治疗中作用的知识。
我们使用通过PubMed获取的Medline索引研究作为主要数据源，对VD和PDAC进行了系统综述。本研究旨在识别关注VD作为PDAC风险和预后因素的作用的文章、评估VD或维生素D类似物（VDAs）在PDAC模型中的作用的机制研究，以及关于PDAC中VDAs的临床试验。筛选后，97项研究被纳入最终稿件。
尽管流行病学研究结果相互矛盾，但基础研究表明，VD可以直接作用于PDAC细胞，抑制其增殖、凋亡、上皮-间质转化、迁移、侵袭和干性，也可以通过基质重塑间接发挥作用。需要更好地理解VD诱导的肿瘤-基质相互作用改变的后果，以确定VD/VDAs是否可以在PDAC治疗中为我们所用。
