Fernandez Francesca, Griffiths Lyn R, Sutherland Heidi G, Cole Michael H, Fitton J Helen, Winberg Pia, Schweitzer Daniel, Hopkins Lloyd N, Meyer Barbara J
School of Behavioural and Health Sciences, Faculty of Heath Sciences, Australian Catholic University, Banyo, QLD 4014, Australia.
Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, 60 Musk Ave, Kelvin Grove, QLD 4059, Australia.
Nutrients. 2024 Nov 27;16(23):4088. doi: 10.3390/nu16234088.
Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved in a wide range of biological processes. Currently, seven mammalian SIRTs have been characterized and are found across a number of cellular compartments. There has been considerable interest in the role of SIRTs in the brain due to their role in a plethora of metabolic- and age-related diseases, including their involvement in learning and memory function in physiological and pathophysiological conditions. Although cognitive function declines over the course of healthy ageing, neurological disorders including Alzheimer's disease (AD) can be associated with progressive cognitive impairments. This review aimed to report and integrate recent advances in the understanding of the role of SIRTs in cognitive function and dysfunction in the context of AD. We have also reviewed the use of selective and/or natural SIRT activators as potential therapeutic agents and/or adjuvants for AD.
沉默调节蛋白（SIRTs）是烟酰胺腺嘌呤二核苷酸（+）依赖性组蛋白脱乙酰酶，已成为许多参与广泛生物过程的信号通路中的关键调节因子。目前，已鉴定出七种哺乳动物SIRTs，它们存在于许多细胞区室中。由于SIRTs在大量与代谢和年龄相关的疾病中发挥作用，包括在生理和病理生理条件下参与学习和记忆功能，因此人们对其在大脑中的作用产生了浓厚兴趣。尽管认知功能在健康衰老过程中会下降，但包括阿尔茨海默病（AD）在内的神经疾病可能与进行性认知障碍有关。本综述旨在报告和整合在理解SIRTs在AD背景下的认知功能和功能障碍中的作用方面的最新进展。我们还综述了使用选择性和/或天然SIRT激活剂作为AD的潜在治疗药物和/或佐剂的情况。
