Azargoonjahromi Ali, Abutalebian Fatemeh
Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Biotechnology and Medicine, Islamic Azad University of Tehran Central Branch, Tehran, Iran.
Nutr Metab (Lond). 2024 Mar 19;21(1):15. doi: 10.1186/s12986-024-00792-1.
Resveratrol (RV), a natural compound found in grapes, berries, and peanuts, has been extensively studied for its potential in treating Alzheimer's disease (AD). RV has shown promise in inhibiting the formation of beta-amyloid plaques (Aβ) and neurofibrillary tangles (NFTs), protecting against neuronal damage and oxidative stress, reducing inflammation, promoting neuroprotection, and improving the function of the blood-brain barrier (BBB). However, conflicting results have been reported, necessitating a comprehensive umbrella review of systematic reviews to provide an unbiased conclusion on the therapeutic effectiveness of RV in AD.
The objective of this study was to systematically synthesize and evaluate systematic and meta-analysis reviews investigating the role of RV in AD using data from both human and animal studies.
Of the 34 systematic and meta-analysis reviews examining the association between RV and AD that were collected, six were included in this study based on specific selection criteria. To identify pertinent studies, a comprehensive search was conducted in English-language peer-reviewed journals without any restrictions on the publication date until October 15, 2023. The search was carried out across multiple databases, including Embase, MEDLINE (PubMed), Cochrane Library, Web of Science, and Google Scholar, utilizing appropriate terms relevant to the specific research field. The AMSTAR-2 and ROBIS tools were also used to evaluate the quality and risk of bias of the included systematic reviews, respectively. Two researchers independently extracted and analyzed the data, resolving any discrepancies through consensus. Of note, the study adhered to the PRIOR checklist.
This umbrella review presented robust evidence supporting the positive impacts of RV in AD, irrespective of the specific mechanisms involved. It indeed indicated that all six systematic and meta-analysis reviews unanimously concluded that the consumption of RV can be effective in the treatment of AD.
RV exhibits promising potential for benefiting individuals with AD through various mechanisms. It has been observed to enhance cognitive function, reduce Aβ accumulation, provide neuroprotection, protect the BBB, support mitochondrial function, facilitate synaptic plasticity, stabilize tau proteins, mitigate oxidative stress, and reduce neuroinflammation commonly associated with AD.
白藜芦醇（RV）是一种存在于葡萄、浆果和花生中的天然化合物，其在治疗阿尔茨海默病（AD）方面的潜力已得到广泛研究。RV在抑制β-淀粉样蛋白斑块（Aβ）和神经原纤维缠结（NFTs）的形成、预防神经元损伤和氧化应激、减轻炎症、促进神经保护以及改善血脑屏障（BBB）功能等方面显示出前景。然而，已有相互矛盾的结果报道，因此有必要对系统评价进行全面的伞状综述，以便就RV在AD治疗中的有效性提供无偏倚的结论。
本研究的目的是系统地综合和评估调查RV在AD中作用的系统评价和荟萃分析，使用来自人类和动物研究的数据。
在收集的34篇研究RV与AD关联的系统评价和荟萃分析中，根据特定选择标准，本研究纳入了6篇。为确定相关研究，在截至2023年10月15日的英语同行评审期刊上进行了全面检索，对出版日期无任何限制。检索在多个数据库中进行，包括Embase、MEDLINE（PubMed）、Cochrane图书馆、科学网和谷歌学术，使用与特定研究领域相关的适当术语。还分别使用AMSTAR-2和ROBIS工具评估纳入的系统评价的质量和偏倚风险。两名研究人员独立提取和分析数据，通过协商解决任何差异。值得注意的是，该研究遵循PRIOR清单。
本伞状综述提供了有力证据，支持RV对AD有积极影响，无论涉及的具体机制如何。确实表明，所有6篇系统评价和荟萃分析一致得出结论，即摄入RV对AD治疗有效。
RV通过多种机制对AD患者显示出有前景的潜力。据观察，它可增强认知功能、减少Aβ积累、提供神经保护、保护血脑屏障、支持线粒体功能、促进突触可塑性、稳定tau蛋白、减轻氧化应激以及减少通常与AD相关的神经炎症。
