Fekete Mónika, Lehoczki Andrea, Csípő Tamás, Fazekas-Pongor Vince, Szappanos Ágnes, Major Dávid, Mózes Noémi, Dósa Norbert, Varga János Tamás
Institute of Preventive Medicine and Public Health, Faculty of Medicine, Semmelweis University, 1089 Budapest, Hungary.
Health Sciences Program, Doctoral College, Semmelweis University, 1085 Budapest, Hungary.
Nutrients. 2024 Nov 28;16(23):4118. doi: 10.3390/nu16234118.
Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory airway disorder characterized by a gradual decline in lung function and increased oxidative stress. Both oxidative stress and inflammation are central to its pathophysiology, with trace elements such as zinc, copper, iron, manganese, magnesium, selenium, and calcium playing key roles in various cellular processes.
This article reviews the role of trace elements in COPD, focusing on their involvement in disease pathogenesis and their therapeutic potential. Specifically, we examine the effects of zinc, copper, iron, magnesium, manganese, selenium, and calcium in COPD.
We performed a comprehensive narrative review of the literature across databases including PubMed, Web of Science, Cochrane Library, and Google Scholar, identifying studies that explore the therapeutic effects of trace elements in COPD. The studies included in the review consisted of cohort analyses, randomized controlled trials, and clinical investigations.
Zinc, copper, iron, magnesium, manganese, selenium, and calcium are critical to both the pathophysiology and management of COPD. These trace elements contribute to the regulation of inflammation, the modulation of oxidative stress, and the maintenance of lung function. Zinc and copper, for instance, reduce oxidative stress and modulate immune responses, while iron is essential for oxygen transport. Magnesium, manganese, selenium, and calcium are vital for muscle function, respiratory performance, reducing inflammation, and improving pulmonary function.
The minerals zinc, copper, iron, magnesium, manganese, selenium, and calcium may contribute to beneficial effects as part of the standard therapeutic management of COPD. Maintaining optimal levels of these trace elements may support the regulation of inflammatory processes, a reduction in oxidative stress, and an improvement in the pulmonary function. However, further clinical research is necessary to confirm their efficacy and establish safe dosage recommendations in COPD treatment.
慢性阻塞性肺疾病（COPD）是一种进行性炎症性气道疾病，其特征是肺功能逐渐下降和氧化应激增加。氧化应激和炎症都是其病理生理学的核心，锌、铜、铁、锰、镁、硒和钙等微量元素在各种细胞过程中发挥关键作用。
本文综述微量元素在COPD中的作用，重点关注它们在疾病发病机制中的参与情况及其治疗潜力。具体而言，我们研究锌、铜、铁、镁、锰、硒和钙在COPD中的作用。
我们对包括PubMed、Web of Science、Cochrane图书馆和谷歌学术在内的数据库中的文献进行了全面的叙述性综述，确定了探索微量元素在COPD中治疗作用的研究。纳入综述的研究包括队列分析、随机对照试验和临床调查。
锌、铜、铁、镁、锰、硒和钙对COPD的病理生理学和管理都至关重要。这些微量元素有助于调节炎症、调节氧化应激和维持肺功能。例如，锌和铜可降低氧化应激并调节免疫反应，而铁对于氧气运输至关重要。镁、锰、硒和钙对于肌肉功能、呼吸性能、减轻炎症和改善肺功能至关重要。
锌、铜、铁、镁、锰、硒和钙等矿物质作为COPD标准治疗管理的一部分可能会产生有益效果。维持这些微量元素的最佳水平可能有助于调节炎症过程、降低氧化应激和改善肺功能。然而，需要进一步的临床研究来证实它们的疗效并确定COPD治疗中的安全剂量建议。
