Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Food Chem Toxicol. 2023 Sep;179:113983. doi: 10.1016/j.fct.2023.113983. Epub 2023 Aug 9.
In the human body, trace elements and other micronutrients play a vital role in growth, health and immune system function. The trace elements are Iron, Manganese, Copper, Iodine, Zinc, Cobalt, Fluoride, and Selenium. Estimating the serum levels of trace elements in hematologic malignancy patients can determine the severity of the tumor. Multiple myeloma (MM) is a hematopoietic malignancy and is characterized by plasma cell clonal expansion in bone marrow. Despite the advances in treatment methods, myeloma remains largely incurable. In addition to conventional medicine, treatment is moving toward less expensive noninvasive alternatives. One of the alternative treatments is the use of dietary supplements. In this review, we focused on the effect of three trace elements including iron, zinc and selenium on important mechanisms such as the immune system, oxidative and antioxidant factors and cell cycle. Using some trace minerals in combination with approved drugs can increase patients' recovery speed. Trace elements can be used as not only a preventive but also a therapeutic tool, especially in reducing inflammation in hematological cancers such as multiple myeloma. We hope that the prospect of the correct use of trace element supplements in the future could be promising for the treatment of diseases.
在人体中，微量元素和其他微量营养素在生长、健康和免疫系统功能中起着至关重要的作用。微量元素包括铁、锰、铜、碘、锌、钴、氟化物和硒。估计血液恶性肿瘤患者的血清微量元素水平可以确定肿瘤的严重程度。多发性骨髓瘤（MM）是一种血液恶性肿瘤，其特征是骨髓中浆细胞克隆性扩张。尽管治疗方法有所进步，但骨髓瘤仍然基本上无法治愈。除了传统医学外，治疗方法正在向更便宜、非侵入性的替代方法发展。替代治疗之一是使用膳食补充剂。在这篇综述中，我们重点关注了三种微量元素（铁、锌和硒）对免疫系统、氧化和抗氧化因素以及细胞周期等重要机制的影响。使用一些痕量矿物质与已批准的药物联合使用可以提高患者的康复速度。微量元素不仅可以作为预防工具，也可以作为治疗工具，特别是在减少血液癌症（如多发性骨髓瘤）中的炎症方面。我们希望未来正确使用微量元素补充剂的前景可能对疾病的治疗有希望。
