Bi Jingjing, Chen Minhao, Nie Pengpeng, Liu Yuanfang, Liu Jun, Du Yuguo
School of Pharmacy, Xinyang Agriculture and Forestry University, Xinyang 464000, China.
School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.
Molecules. 2024 Nov 21;29(23):5500. doi: 10.3390/molecules29235500.
A divergent total synthesis of bioactive, naturally occurring decanolides, pinolidoxin and bellidisin C, was accomplished by taking advantage of chiral templates -ribose and -malic acid. In particular, bellidisin C, which is the first total synthesis so far, was achieved through a cascade reaction of reductive elimination and nucleophilic addition in a one-pot process and a sodium-alkoxide-promoted intramolecular lactonization as the key steps.
通过利用手性模板——核糖和苹果酸，完成了具有生物活性的天然癸内酯、松果毒素和美丽马醉木苷C的发散式全合成。特别是，美丽马醉木苷C的全合成是首次实现，它通过一锅法中还原消除和亲核加成的串联反应以及钠醇盐促进的分子内内酯化作为关键步骤来完成。
