有序介孔二氧化硅材料在药物递送中的应用：综述

Application of Ordered Porous Silica Materials in Drug Delivery: A Review.

作者信息

Liu Wenwen, Wu Junlin, Jiang Zehao, Zhang Xinyu, Wang Zhenxiang, Meng Fanjun, Liu Zidi, Zhang Teng

机构信息

Nanjing University of Science and Technology Hospital, Nanjing University of Science and Technology, Nanjing 210094, China.

School of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, China.

出版信息

Molecules. 2024 Dec 3;29(23):5713. doi: 10.3390/molecules29235713.

DOI:10.3390/molecules29235713

PMID:39683872

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643771/

Abstract

Nanotechnology has significantly advanced various fields, including therapeutic delivery, through the use of nanomaterials as drug carriers. The biocompatibility of ordered porous silica materials makes them promising candidates for drug delivery systems, particularly in the treatment of cancer and other diseases. This review summarizes the use of microporous zeolites and mesoporous silica materials in drug delivery, focusing on their physicochemical properties and applications as drug carriers. Special emphasis is placed on strategies for encapsulation and functionalization, highlighting their role in enhancing drug loading and enabling targeted delivery. In conclusion, while ordered porous silica materials hold great potential for drug delivery systems, certain challenges remain.

摘要

纳米技术通过使用纳米材料作为药物载体，在包括治疗递送在内的各个领域都取得了显著进展。有序多孔二氧化硅材料的生物相容性使其成为药物递送系统的有前途的候选材料，特别是在癌症和其他疾病的治疗中。本综述总结了微孔沸石和介孔二氧化硅材料在药物递送中的应用，重点关注它们作为药物载体的物理化学性质和应用。特别强调了封装和功能化策略，突出了它们在提高药物负载量和实现靶向递送方面的作用。总之，虽然有序多孔二氧化硅材料在药物递送系统中具有巨大潜力，但仍存在一些挑战。