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基于介孔硅纳米粒子的癌症控制药物输送系统。

Controlled drug delivery systems for cancer based on mesoporous silica nanoparticles.

机构信息

Nanomedicine Group, University of Cantabria - IDIVAL, Santander, 39011, Spain.

Department of Physical Chemistry, Center for Biomedical Research (CINBIO), Southern Galicia Institute of Health Research (IISGS), Vigo 36310, Spain.

出版信息

Int J Nanomedicine. 2019 May 8;14:3389-3401. doi: 10.2147/IJN.S198848. eCollection 2019.

Abstract

The implementation of nanotechnology in medicine has opened new research horizons particularly in the field of therapeutic delivery. Mesoporous silica particles have emerged as biocompatible drug delivery systems with an enormous potential in the treatment of cancer among many other pathologies. In this review, we focus on the unique properties of these particles as chemotherapy delivery carriers. Here, we summarize the general characteristics of these nanomaterials - including their physicochemical properties and customizable surfaces - different stimuli that can be used to trigger targeted drug release, biocompatibility and finally, the drawbacks of these types of nanomaterials, highlighting some of the most important features of mesoporous silica nanoparticles in drug delivery.

摘要

纳米技术在医学中的应用开辟了新的研究领域,特别是在治疗药物输送领域。介孔硅颗粒作为生物相容性的药物输送系统,具有治疗癌症等多种疾病的巨大潜力。在这篇综述中,我们重点介绍了这些颗粒作为化疗药物输送载体的独特性质。在这里,我们总结了这些纳米材料的一般特性——包括它们的物理化学性质和可定制的表面——可以用来触发靶向药物释放的不同刺激,生物相容性,最后是这些类型的纳米材料的缺点,强调了介孔硅纳米颗粒在药物输送中的一些最重要的特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6de8/6512630/60004bc00345/IJN-14-3389-g0001.jpg

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