Liao Lixia, Zhang Jiyuan, Ding Jiaqi, Xu Chengzhi, Zhu Lian, Hou Yuanjing, Li Sheng, Zhang Juntao, Wei Benmei, Wang Haibo
School of Chemistry and Environmental Engineering, Wuhan Polytechnic University, Wuhan 430023, China.
Hubei Key Laboratory of Quality Control of Characteristic Fruits and Vegetables, College of Life Science and Technology, Hubei Engineering University, Xiaogan 432000, China.
Molecules. 2024 Dec 4;29(23):5728. doi: 10.3390/molecules29235728.
The conductive hydrogels (CHs) are promising for developing flexible energy storage devices, flexible sensors, and electronic skin due to the unique features of excellent flexibility and high conductivity. However, poor biocompatibility and antibacterial properties seriously limit their application in the biomedical field. Collagen, one of the main components of the extracellular Matrix (ECM), is the ideal matrix for constructing hydrogels due to good biocompatibility with human tissue. Here, dopamine-polypyrrole-collagen (DA-PPY-COL) hydrogel was constructed by dopamine-mediated pyrrole in situ polymerization in a collagen matrix. As a strain sensor, it can be affixed to different parts of the human body to monitor large-scale motion movements and fine micro-expressions in real time. The performance was attributed to its good self-adhesion, flexibility, and electrical conductivity. Biological experiments have shown that it has good antimicrobial properties, biocompatibility, and degradability, allowing the hydrogel to safely monitor human motor behavior. This work not only offers a material preparation strategy for constructing biomimetic electronic skin and wearable sensors but also demonstrates the great potential prospect for implantable degradable medical device applications.
导电水凝胶（CHs）因其具有出色的柔韧性和高导电性等独特特性，在开发柔性储能设备、柔性传感器和电子皮肤方面具有广阔前景。然而，其较差的生物相容性和抗菌性能严重限制了它们在生物医学领域的应用。胶原蛋白是细胞外基质（ECM）的主要成分之一，由于与人体组织具有良好的生物相容性，是构建水凝胶的理想基质。在此，通过多巴胺介导吡咯在胶原蛋白基质中原位聚合制备了多巴胺 - 聚吡咯 - 胶原蛋白（DA - PPY - COL）水凝胶。作为一种应变传感器，它可以粘贴在人体的不同部位，实时监测大规模运动和细微的微表情。其性能归因于良好的自粘性、柔韧性和导电性。生物学实验表明，它具有良好的抗菌性能、生物相容性和可降解性，使得该水凝胶能够安全地监测人体运动行为。这项工作不仅为构建仿生电子皮肤和可穿戴传感器提供了一种材料制备策略，还展示了其在可植入可降解医疗设备应用方面的巨大潜在前景。
