Yang Hanyu, Yang Jiaxin, Zheng Xiang, Chen Tianshun, Zhang Ranqi, Chen Rui, Cao Tingting, Zeng Fancai, Liu Qiuyu
School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Laboratory of Biochemistry and Molecular Biology, School of Basic Medical Science, Southwest Medical University, Luzhou 646000, China.
Int J Mol Sci. 2024 Nov 29;25(23):12868. doi: 10.3390/ijms252312868.
As one of the most prevalent malignant neoplasms among women globally, the optimization of therapeutic strategies for breast cancer has perpetually been a research hotspot. The tumor microenvironment (TME) is of paramount importance in the progression of breast cancer, among which the extracellular matrix (ECM) and hypoxia are two crucial factors. The alterations of these two factors are predominantly regulated by the Hippo signaling pathway, which promotes tumor invasiveness, metastasis, therapeutic resistance, and susceptibility. Hence, this review focuses on the Hippo pathway in breast cancer, specifically, how the ECM and hypoxia impact the biological traits and therapeutic responses of breast cancer. Moreover, the role of miRNAs in modulating ECM constituents was investigated, and hsa-miR-33b-3p was identified as a potential therapeutic target for breast cancer. The review provides theoretical foundations and potential therapeutic direction for clinical treatment strategies in breast cancer, with the aspiration of attaining more precise and effective treatment alternatives in the future.
作为全球女性中最常见的恶性肿瘤之一，乳腺癌治疗策略的优化一直是研究热点。肿瘤微环境（TME）在乳腺癌进展中至关重要，其中细胞外基质（ECM）和缺氧是两个关键因素。这两个因素的改变主要由Hippo信号通路调节，该通路促进肿瘤侵袭、转移、治疗抗性和易感性。因此，本综述聚焦于乳腺癌中的Hippo通路，具体而言，ECM和缺氧如何影响乳腺癌的生物学特性和治疗反应。此外，研究了miRNA在调节ECM成分中的作用，并确定hsa-miR-33b-3p为乳腺癌的潜在治疗靶点。该综述为乳腺癌临床治疗策略提供了理论基础和潜在治疗方向，以期未来获得更精确有效的治疗方案。
