Ke Bo-Jun, Dragoni Gabriele, Matteoli Gianluca
Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Chronic Diseases and Metabolism, KU Leuven, 3000 Leuven, Belgium.
Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.
Int J Mol Sci. 2024 Dec 3;25(23):13008. doi: 10.3390/ijms252313008.
Intestinal fibroblasts are pivotal players in maintaining tissue homeostasis and orchestrating responses to injury and inflammation within the gastrointestinal (GI) tract. Fibroblasts contribute significantly to the pathogenesis of inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis (UC), by secreting pro-inflammatory cytokines, modulating immune cell activity, and promoting fibrosis. In addition, fibroblasts play crucial roles in tissue repair and regeneration following acute injury or chronic inflammation. The dysregulation of fibroblast functions can lead to fibrotic complications, such as intestinal strictures and obstruction, which are common in advanced stages of IBD. Understanding the complex interplay between fibroblasts and other cell types in the intestine is essential to elucidate the underlying mechanisms of intestinal diseases and identify novel therapeutic targets. Future research aimed at deciphering the heterogeneity of intestinal fibroblasts and their dynamic roles in disease progression holds promise for the development of precision therapies to mitigate fibrosis and inflammation in intestinal disorders.
肠道成纤维细胞是维持组织稳态以及协调胃肠道（GI）对损伤和炎症反应的关键参与者。成纤维细胞通过分泌促炎细胞因子、调节免疫细胞活性和促进纤维化，在炎症性肠病（IBD）（包括克罗恩病和溃疡性结肠炎（UC））的发病机制中发挥重要作用。此外，成纤维细胞在急性损伤或慢性炎症后的组织修复和再生中起关键作用。成纤维细胞功能失调可导致纤维化并发症，如肠道狭窄和梗阻，这在IBD晚期很常见。了解肠道中成纤维细胞与其他细胞类型之间的复杂相互作用对于阐明肠道疾病的潜在机制和确定新的治疗靶点至关重要。旨在破译肠道成纤维细胞异质性及其在疾病进展中的动态作用的未来研究，有望开发出精准疗法来减轻肠道疾病中的纤维化和炎症。
