Aljama Cristina, Esquinas Cristina, Loeb Eduardo, Granados Galo, Nuñez Alexa, Lopez-Gonzalez Ane, Miravitlles Marc, Barrecheguren Miriam
Department of Pneumology, Universitary Hospital Vall d'Hebron/Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain.
Department of Public Health, Mental Health and Maternal and Child Health Nursing, Faculty of Nursing, University of Barcelona (UB), 08007 Barcelona, Spain.
J Clin Med. 2024 Dec 4;13(23):7380. doi: 10.3390/jcm13237380.
Early, mild and young COPD concepts are not clearly defined and are often used interchangeably to refer to the onset of the disease. : To describe and compare the characteristics of mild, young and early COPD in a large sample of COPD from primary and secondary care. : Pooled analysis of individual data from four multicenter observational studies of patients with stable COPD (≥40 years, FEV/FVC < 0.7, smoking ≥ 10 pack-years). Mild COPD was defined as FEV% ≥ 65%; young COPD as <55 years; and early COPD as <55 years and smoking ≤ 20 pack-years. The relationship between FEV(%), age and pack-years was analyzed with linear regression equations. : We included 5468 patients. Their mean age was 67 (SD: 9.6) years, and 85% were male. A total of 1158 (21.2%) patients had mild COPD; 636 (11.6%) had young COPD and 191 (3.5%) early COPD. The three groups shared common characteristics: they were more frequently female, younger and with less tobacco exposure compared with the remaining patients. Early COPD had fewer comorbidities and fewer COPD admissions, but no significant differences were found in ambulatory exacerbations. In linear regression analysis, the decline in FEV(%) was more pronounced for the first 20 pack-years for all age groups and was even more important in younger patients. : Mild, young and early COPD patients were more frequently women. The steepest decline in FEV(%) was observed in individuals <55 years and smoking between 10 and 20 pack-years (early COPD), which highlights the importance of an early detection and implementation of preventive and therapeutic measures.
早期、轻度和年轻慢性阻塞性肺疾病（COPD）的概念尚未明确界定，常被互换使用以指代该疾病的发病情况。：描述并比较来自初级和二级医疗保健机构的大量COPD样本中轻度、年轻和早期COPD的特征。：对四项关于稳定期COPD患者（≥40岁，FEV/FVC<0.7，吸烟≥10包年）的多中心观察性研究的个体数据进行汇总分析。轻度COPD定义为FEV%≥65%；年轻COPD定义为年龄<55岁；早期COPD定义为年龄<55岁且吸烟≤20包年。使用线性回归方程分析FEV（%）、年龄和吸烟包年之间的关系。：我们纳入了5468例患者。他们的平均年龄为67（标准差：9.6）岁，85%为男性。共有1158例（21.2%）患者患有轻度COPD；636例（11.6%）患有年轻COPD，191例（3.5%）患有早期COPD。这三组具有共同特征：与其余患者相比，她们更常为女性、年龄更小且烟草暴露更少。早期COPD的合并症和COPD住院次数更少，但在门诊加重方面未发现显著差异。在线性回归分析中，所有年龄组在前20包年中FEV（%）的下降更为明显，在年轻患者中更为重要。：轻度、年轻和早期COPD患者更常为女性。在年龄<55岁且吸烟量在10至20包年之间的个体（早期COPD）中观察到FEV（%）下降最为陡峭，这突出了早期检测以及实施预防和治疗措施的重要性。
