Summers P M, Wennink C J, Hodges J K
J Reprod Fertil. 1985 Jan;73(1):133-8. doi: 10.1530/jrf.0.0730133.
A single intramuscular injection of 0.5 micrograms cloprostenol was not luteolytic on Day 6 or 7 of the ovarian cycle (N = 3), but was luteolytic in some animals (3/5) on Day 8 and 9 and luteolytic in all 23 animals treated between Days 10 and 17 of the ovarian cycle, and in 7 animals treated between Days 19 and 43 of pregnancy. Luteal function was monitored by measurement of progesterone in peripheral blood using a simple and rapid non-extraction assay. There was a dramatic fall in peripheral blood progesterone to less than 10 ng/ml within 24 h of cloprostenol injection; progesterone remained at this low level until the day after post-treatment ovulation. The interval from cloprostenol injection to ovulation in animals treated between Days 8 and 17 was 10.7 +/- 0.3 days. A similar interval was found in pregnant animals. Embryos recovered from the uterus after cloprostenol treatment were morphologically normal (23/24).
在卵巢周期的第6天或第7天，单次肌内注射0.5微克氯前列醇不会引起黄体溶解（N = 3），但在第8天和第9天，部分动物（3/5）会出现黄体溶解，在卵巢周期第10天至17天接受治疗的所有23只动物以及妊娠第19天至43天接受治疗的7只动物中均出现黄体溶解。通过使用简单快速的非提取测定法测量外周血中的孕酮来监测黄体功能。氯前列醇注射后24小时内，外周血孕酮急剧下降至低于10 ng/ml；孕酮在治疗后排卵后的第二天仍维持在低水平。在第8天至17天接受治疗的动物中，从氯前列醇注射到排卵的间隔为10.7 +/- 0.3天。在怀孕动物中也发现了类似的间隔。氯前列醇治疗后从子宫中回收的胚胎形态正常（23/24）。
