Varsanyi Christopher, Birge Raymond B
Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, United States.
J Leukoc Biol. 2024 Dec 31;117(1). doi: 10.1093/jleuko/qiae253.
While widely viewed as inhibitory receptors that drive efferocytosis and immune resolution on myeloid cells, TAM family members, particularly Mertk, have emerged as promising targets in immune-oncology to help stimulate host antitumor immunity. A recent study shows that Mertk expressed on human T cells, including CD8+ T cells and differentiated central memory T cells, has a co-stimulatory function for the T Cell Receptor. These new findings reveal the complexity and diversification of Mertk in immune regulation and its implications to cancer therapeutics.
虽然TAM家族成员，特别是Mertk，被广泛视为驱动髓系细胞上的噬菌作用和免疫消退的抑制性受体，但它们已成为免疫肿瘤学中有望帮助刺激宿主抗肿瘤免疫的靶点。最近的一项研究表明，在人类T细胞（包括CD8 + T细胞和分化的中央记忆T细胞）上表达的Mertk对T细胞受体具有共刺激功能。这些新发现揭示了Mertk在免疫调节中的复杂性和多样性及其对癌症治疗的意义。
