血液学标志物作为多发性硬化症进展的预后指标
Hematological markers as prognostic indicators in multiple sclerosis progression.
作者信息
Poursadeghfard Maryam, Shiati Samin, Salehi Mohammad Saied, Khani Aryan, Vafaeian Soheil, Bayat Mahnaz, Hooshmandi Etrat
机构信息
Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Biomark Med. 2025 Jan;19(1):5-12. doi: 10.1080/17520363.2024.2441106. Epub 2024 Dec 17.
AIMS
To evaluate routine blood count parameters as diagnostic and prognostic markers in Multiple Sclerosis (MS) progression.
PATIENTS/METHODS: 182 patients with Relapsing-Remitting MS (RRMS) and 60 with Secondary Progressive MS (SPMS) were analyzed for blood parameters.
RESULTS
In RRMS, the Expanded Disability Status Scale (EDSS) score correlated positively with Red Cell Distribution Width (RDW). In SPMS, the EDSS score correlated positively with White Blood Cell count (WBC) and Mean Platelet Volume (MPV). RDW predicted higher EDSS scores in RRMS, while MPV was a predictor in SPMS. Elevated MPV levels characterized the increased risk of transitioning from RRMS to SPMS.
CONCLUSIONS
Elevated MPV may serve as a significant indicator of disease progression from RRMS to SPMS, emphasizing its potential clinical relevance.
目的
评估血常规参数作为多发性硬化症（MS）病情进展的诊断和预后标志物。
患者/方法：对182例复发缓解型多发性硬化症（RRMS）患者和60例继发进展型多发性硬化症（SPMS）患者的血液参数进行分析。
结果
在RRMS中，扩展残疾状态量表（EDSS）评分与红细胞分布宽度（RDW）呈正相关。在SPMS中，EDSS评分与白细胞计数（WBC）和平均血小板体积（MPV）呈正相关。RDW可预测RRMS患者更高的EDSS评分，而MPV是SPMS的预测指标。MPV水平升高是RRMS向SPMS转变风险增加的特征。
结论
MPV升高可能是RRMS向SPMS疾病进展的重要指标，强调了其潜在的临床相关性。
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