A dual functional mucus- and cell-penetrating peptide enhances mRNA lipid nanoparticle delivery to the lung.
作者信息
Kumar Sahana, Duncan Gregg A
机构信息
Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
Molecular and Cellular Biology Program, University of Maryland, College Park, MD 20742, USA.
出版信息
Mol Ther Nucleic Acids. 2024 Nov 29;35(4):102393. doi: 10.1016/j.omtn.2024.102393. eCollection 2024 Dec 10.
Abstract
摘要
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本文引用的文献
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Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia.发现用于将mRNA脂质纳米颗粒通过配体介导递送至囊性纤维化肺上皮细胞的肽。
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2
Advances in gene therapy for cystic fibrosis lung disease.囊性纤维化肺病的基因治疗进展。
Hum Mol Genet. 2019 Oct 1;28(R1):R88-R94. doi: 10.1093/hmg/ddz139.
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The Mucus Barrier to Inhaled Gene Therapy.吸入式基因治疗的黏液屏障
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On the Pathogenesis of Acute Exacerbations of Mucoobstructive Lung Diseases.关于黏液阻塞性肺部疾病急性加重的发病机制
Ann Am Thorac Soc. 2015 Nov;12 Suppl 2(Suppl 2):S160-3. doi: 10.1513/AnnalsATS.201507-460AW.
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N Engl J Med. 2015 Apr 16;372(16):1574-5. doi: 10.1056/NEJMc1502191.
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