Chang Hao, Li Gaiyan, He Dongjie, Zhu Siying, Jing Yong, Liu Honggang, Li Junting, Wu Peiwen, Shao Qiuju
Department of Radiation Oncology, Tangdu Hospital, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Department of Radiology, Tangdu Hospital, The Second Affiliated Hospital of Air Force Medical University, Xi'an, China.
Can Respir J. 2024 Dec 9;2024:4792750. doi: 10.1155/carj/4792750. eCollection 2024.
Thymoma is a common malignancy with low incidence, and pleural metastases are common pattern of recurrence. It is necessary that the spatial location of pleural metastatic lesions be analyzed. This study aimed to analyze the spatial distribution patterns of pleural dissemination in patients with thymoma and evaluate the variables that influence the survival of pleural metastasis in this population. This retrospective study investigated hospital admissions of patients diagnosed with pleural metastasis from thymoma. The spatial distribution pattern and visualization of the pleural metastases were analyzed after establishing a coordinate system. We further analyzed the survival and influencing factors in patients with pleural metastases from thymoma. The analysis included 56 patients with a cumulative count of 365 pleural metastases, with 351 metastases from Zones 1-5 finally included in the analysis. The spatial distribution of the 285 initially diagnosed pleural metastases was significantly concentrated in Zones 3 and 4 near the lateral half of the spine (56.5%), followed by Zone 5 (17.5%). Collectively, these two components accounted for 74.0% (211/285) of all initial metastatic lesions. The survival rates at 5 years for those who underwent surgery versus nonsurgical treatment were 68.3% and 37.1%, respectively (=0.015). Univariate Cox regression analysis showed that surgical intervention reduced the risk of death by 61%. The distribution of pleural metastatic lesions exhibited a nonuniform pattern, primarily concentrated on the spinal aspect below the aortic arch of the costal pleura and the spinal aspect of the diaphragmatic pleura.
胸腺瘤是一种发病率较低的常见恶性肿瘤，胸膜转移是常见的复发模式。分析胸膜转移病灶的空间位置很有必要。本研究旨在分析胸腺瘤患者胸膜播散的空间分布模式，并评估影响该人群胸膜转移患者生存的变量。这项回顾性研究调查了被诊断为胸腺瘤胸膜转移患者的住院情况。建立坐标系后，分析胸膜转移灶的空间分布模式和可视化情况。我们进一步分析了胸腺瘤胸膜转移患者的生存情况及影响因素。分析纳入了56例患者，累计胸膜转移灶365个，最终351个转移灶纳入分析，这些转移灶来自第1 - 5区。最初诊断的285个胸膜转移灶的空间分布显著集中在脊柱外侧半附近的第3区和第4区（56.5%），其次是第5区（17.5%）。总体而言，这两个区域占所有初始转移病灶的74.0%（211/285）。接受手术与未接受手术治疗的患者5年生存率分别为68.3%和37.1%（=0.015）。单因素Cox回归分析显示，手术干预使死亡风险降低了61%。胸膜转移病灶的分布呈现出不均匀的模式，主要集中在肋胸膜主动脉弓下方的脊柱侧以及膈胸膜的脊柱侧。
