• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

利用m1A修饰：癌症免疫治疗的新前沿。

Harnessing m1A modification: a new frontier in cancer immunotherapy.

作者信息

Wang Xinru, Ma Xiaoqing, Chen Siyu, Fan Minyan, Jin Chenying, Chen Yushi, Wang Shaodong, Wang Zhiying, Meng Fei, Zhang Chengwan, Yang Lin

机构信息

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.

Affiliated Nanjing Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu, China.

出版信息

Front Immunol. 2024 Dec 2;15:1517604. doi: 10.3389/fimmu.2024.1517604. eCollection 2024.

DOI:10.3389/fimmu.2024.1517604
PMID:39687616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11647001/
Abstract

N1-methyladenosine (m1A) modification is an epigenetic change that occurs on RNA molecules, regulated by a suite of enzymes including methyltransferases (writers), demethylases (erasers), and m1A-recognizing proteins (readers). This modification significantly impacts the function of RNA and various biological processes by affecting the structure, stability, translation, metabolism, and gene expression of RNA. Thereby, m1A modification is closely associated with the occurrence and progression of cancer. This review aims to explore the role of m1A modification in tumor immunity. m1A affects tumor immune responses by directly regulating immune cells and indirectly modulating tumor microenvironment. Besides, we also discuss the implications of m1A-mediated metabolic reprogramming and its nexus with immune checkpoint inhibitors, unveiling promising avenues for immunotherapeutic intervention. Additionally, the m1AScore, established based on the expression patterns of m1A modification, can be used to predict tumor prognosis and guide personalized therapy. Our review underscores the significance of m1A modification as a burgeoning frontier in cancer biology and immuno-oncology, with the potential to revolutionize cancer treatment strategies.

摘要

N1-甲基腺苷（m1A）修饰是一种发生在RNA分子上的表观遗传变化，受包括甲基转移酶（写入器）、去甲基化酶（擦除器）和m1A识别蛋白（读取器）在内的一系列酶的调控。这种修饰通过影响RNA的结构、稳定性、翻译、代谢和基因表达，对RNA的功能和各种生物学过程产生重大影响。因此，m1A修饰与癌症的发生和发展密切相关。本综述旨在探讨m1A修饰在肿瘤免疫中的作用。m1A通过直接调节免疫细胞和间接调节肿瘤微环境来影响肿瘤免疫反应。此外，我们还讨论了m1A介导的代谢重编程的意义及其与免疫检查点抑制剂的关系，揭示了免疫治疗干预的有前景的途径。此外，基于m1A修饰的表达模式建立的m1AScore可用于预测肿瘤预后并指导个性化治疗。我们的综述强调了m1A修饰作为癌症生物学和免疫肿瘤学中一个新兴前沿领域的重要性，有可能彻底改变癌症治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/afa59da007e8/fimmu-15-1517604-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/a6bc158e9023/fimmu-15-1517604-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/1c7951c3bc62/fimmu-15-1517604-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/70058e2da79b/fimmu-15-1517604-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/f066c3093a3e/fimmu-15-1517604-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/afa59da007e8/fimmu-15-1517604-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/a6bc158e9023/fimmu-15-1517604-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/1c7951c3bc62/fimmu-15-1517604-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/70058e2da79b/fimmu-15-1517604-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/f066c3093a3e/fimmu-15-1517604-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/06d5/11647001/afa59da007e8/fimmu-15-1517604-g005.jpg

相似文献

1
Harnessing m1A modification: a new frontier in cancer immunotherapy.利用m1A修饰：癌症免疫治疗的新前沿。
Front Immunol. 2024 Dec 2;15:1517604. doi: 10.3389/fimmu.2024.1517604. eCollection 2024.
2
Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer.全面分析卵巢癌中 N1-甲基腺苷修饰模式和免疫特征。
Front Immunol. 2021 Oct 29;12:746647. doi: 10.3389/fimmu.2021.746647. eCollection 2021.
3
m6A epitranscriptomic modification in hepatocellular carcinoma: implications for the tumor microenvironment and immunotherapy.肝细胞癌中的m6A表观转录组修饰：对肿瘤微环境和免疫治疗的影响
Front Immunol. 2025 Feb 17;16:1538658. doi: 10.3389/fimmu.2025.1538658. eCollection 2025.
4
Landscape of N1-methyladenosin (m1A) modification pattern in colorectal cancer.结直肠癌中 N1-甲基腺苷（m1A）修饰模式的全景图。
Cancer Rep (Hoboken). 2024 Feb;7(2):e1965. doi: 10.1002/cnr2.1965. Epub 2023 Dec 20.
5
Research progress of N1-methyladenosine RNA modification in cancer.N1-甲基腺苷 RNA 修饰在癌症中的研究进展。
Cell Commun Signal. 2024 Jan 30;22(1):79. doi: 10.1186/s12964-023-01401-z.
6
N1-methyladenosine RNA methylation patterns are associated with an increased risk to biochemical recurrence in prostate cancer and serve as a potential novel biomarker for patient stratification.N1-甲基腺苷 RNA 甲基化模式与前列腺癌生化复发风险增加相关，并可作为患者分层的潜在新型生物标志物。
Int Immunopharmacol. 2024 Dec 25;143(Pt 2):113404. doi: 10.1016/j.intimp.2024.113404. Epub 2024 Oct 20.
7
The role of RNA methylation in tumor immunity and its potential in immunotherapy.RNA 甲基化在肿瘤免疫中的作用及其在免疫治疗中的潜力。
Mol Cancer. 2024 Jun 20;23(1):130. doi: 10.1186/s12943-024-02041-8.
8
The Impact of m1A Methylation Modification Patterns on Tumor Immune Microenvironment and Prognosis in Oral Squamous Cell Carcinoma.m1A 甲基化修饰模式对口腔鳞状细胞癌肿瘤免疫微环境和预后的影响。
Int J Mol Sci. 2021 Sep 24;22(19):10302. doi: 10.3390/ijms221910302.
9
Surmounting cancer drug resistance: New insights from the perspective of N-methyladenosine RNA modification.克服癌症药物耐药性：N6-甲基腺苷 RNA 修饰视角的新见解。
Drug Resist Updat. 2020 Dec;53:100720. doi: 10.1016/j.drup.2020.100720. Epub 2020 Aug 20.
10
m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma.肝细胞癌中的 m1A 甲基化修饰模式和代谢特征。
BMC Gastroenterol. 2022 Mar 3;22(1):93. doi: 10.1186/s12876-022-02160-w.

引用本文的文献

1
M6A RNA modification: focusing on non-small cell lung cancer progression, therapeutic strategies and challenges.m6A RNA修饰：聚焦于非小细胞肺癌的进展、治疗策略及挑战
Front Oncol. 2025 Jul 16;15:1622359. doi: 10.3389/fonc.2025.1622359. eCollection 2025.
2
Quantifying the mRNA epitranscriptome reveals epitranscriptome signatures and roles in cancer.对信使核糖核酸表观转录组进行定量分析揭示了表观转录组特征及其在癌症中的作用。
Cell Mol Life Sci. 2025 Jul 28;82(1):290. doi: 10.1007/s00018-025-05805-7.

本文引用的文献

1
Macrophages as Potential Therapeutic Targets in Acute Myeloid Leukemia.巨噬细胞作为急性髓系白血病潜在的治疗靶点
Biomedicines. 2024 Oct 11;12(10):2306. doi: 10.3390/biomedicines12102306.
2
CD4 T cells in antitumor immunity.抗肿瘤免疫中的CD4 T细胞。
Trends Cancer. 2024 Oct;10(10):969-985. doi: 10.1016/j.trecan.2024.07.009. Epub 2024 Sep 5.
3
Abundant mRNA mA modification in dinoflagellates: a new layer of gene regulation.甲藻中丰富的 mRNA mA 修饰：基因调控的新层次。
EMBO Rep. 2024 Nov;25(11):4655-4673. doi: 10.1038/s44319-024-00234-2. Epub 2024 Sep 2.
4
Tumor battlefield within inflamed, excluded or desert immune phenotypes: the mechanisms and strategies.炎症性、排除性或无反应性免疫表型中的肿瘤微环境：机制与策略
Exp Hematol Oncol. 2024 Aug 6;13(1):80. doi: 10.1186/s40164-024-00543-1.
5
tRNA mA modification regulate HSC maintenance and self-renewal via mTORC1 signaling.tRNA mA 修饰通过 mTORC1 信号调节造血干细胞的维持和自我更新。
Nat Commun. 2024 Jul 8;15(1):5706. doi: 10.1038/s41467-024-50110-9.
6
Tracking-seq reveals the heterogeneity of off-target effects in CRISPR-Cas9-mediated genome editing.追踪测序揭示了CRISPR-Cas9介导的基因组编辑中脱靶效应的异质性。
Nat Biotechnol. 2025 May;43(5):799-810. doi: 10.1038/s41587-024-02307-y. Epub 2024 Jul 2.
7
Sequencing methods and functional decoding of mRNA modifications.mRNA修饰的测序方法与功能解码
Fundam Res. 2023 Jun 1;3(5):738-748. doi: 10.1016/j.fmre.2023.05.010. eCollection 2023 Sep.
8
Mass-Spectrometry-Based Assay at Single-Base Resolution for Simultaneously Detecting mA and mAm in RNA.基于质谱的单碱基分辨率测定法，用于同时检测 RNA 中的 mA 和 mAm
Anal Chem. 2024 Jul 16;96(28):11126-11136. doi: 10.1021/acs.analchem.3c04003. Epub 2024 Jun 24.
9
Structural basis for human mitochondrial tRNA maturation.人类线粒体 tRNA 成熟的结构基础。
Nat Commun. 2024 Jun 1;15(1):4683. doi: 10.1038/s41467-024-49132-0.
10
mA inhibition fuels oncolytic virus-elicited antitumor immunity via downregulating MYC/PD-L1 signaling.mA 抑制通过下调 MYC/PD-L1 信号来促进溶瘤病毒引发的抗肿瘤免疫。
Int J Oral Sci. 2024 May 10;16(1):36. doi: 10.1038/s41368-024-00304-0.