Palmirotta Raffaele, Cafiero Concetta, Colella Marica
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari 70124, Italy.
Area of Molecular Pathology, Anatomic Pathology Unit, Fabrizio Spaziani Hospital, Frosinone 03100, Italy.
World J Clin Cases. 2024 Dec 16;12(35):6859-6863. doi: 10.12998/wjcc.v12.i35.6859.
() infections may cause chronic gastritis, peptic ulcer disease, gastric cancers, and other conditions outside of the gastrointestinal tract. Hence, it is important to diagnose and treat it early. is resistant to certain drugs in traditional eradication therapy, so alternative therapy protocols are needed, such as high-dose amoxicillin dual therapy (HDADT). This article aims to comment on a recent paper by Costigan in the . In this study, the authors recruited 139 patients diagnosed with , all treated with HDADT. Of these, 93 were treatment-naïve and 46 had received at least one alternative treatment in the past. Four weeks after the end of the treatment, the urea breath test was administered to estimate the eradication rate. The total eradication rate was 56% (78/139), 62% for the treatment-naïve arm and 43% for the previous treatment arm, thus indicating a lower success rate for the arm that had previously received a different treatment regimen. In conclusion, a therapeutic approach with first-line HDADT may potentially be a better treatment, but the results are not sufficient to recommend the use of this regimen in a country with high levels of dual resistance.
（）感染可能会导致慢性胃炎、消化性溃疡疾病、胃癌以及胃肠道以外的其他病症。因此，尽早诊断和治疗至关重要。（）对传统根除疗法中的某些药物具有抗性，所以需要替代治疗方案，例如高剂量阿莫西林双重疗法（HDADT）。本文旨在对科斯蒂根（Costigan）近期发表在《》上的一篇论文进行评论。在这项研究中，作者招募了139名被诊断为（）的患者，均接受了HDADT治疗。其中，93名患者未曾接受过治疗，46名患者过去至少接受过一种替代治疗。治疗结束四周后，进行尿素呼气试验以评估根除率。总根除率为56%（78/139），未曾接受过治疗的患者组根除率为62%，先前接受过治疗的患者组根除率为43%，这表明先前接受过不同治疗方案的患者组成功率较低。总之，一线HDADT治疗方法可能是一种更好的治疗方法，但研究结果不足以推荐在双重耐药水平较高的国家使用该方案。
