Mores Ana Letícia, Bonfim-Alves Carolina Guimarães, López Rossana Verónica Mendoza, Rodrigues-Oliveira Leticia, Palmier Natália Rangel, Mariz Bruno Augusto Linhares Almeida, Migliorati Cesar Augusto, Kowalski Luiz Paulo, Santos-Silva Alan Roger, Brandão Thaís Bianca, Prado-Ribeiro Ana Carolina
Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Dental Oncology Service, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (ICESP-FMUSP), São Paulo, Brazil.
Oral Dis. 2025 Apr;31(4):1133-1139. doi: 10.1111/odi.15196. Epub 2024 Dec 17.
Evaluate the sociodemographic, clinical, and lifestyle characteristics at head and neck squamous cell carcinoma (HNSCC) diagnosis and their impact on overall survival (OS) across different anatomical sites.
A retrospective cohort study (2011-2021) at Instituto do Câncer do Estado de São Paulo, involving 3052 HNSCC patients. Survival analyses utilized the Kaplan-Meier method and Cox proportional hazard ratios with 95% confidence intervals, incorporating significant variables from univariate analysis.
The five-year OS for all HNSCC sites (n = 3052) was 31.4%, with specific rates of 37.0% for laryngeal cancer (n = 935), 35.8% for oral cancer (n = 762), 26.6% for oropharyngeal cancer (OPC) (n = 1189), and 14.8% for hypopharyngeal cancer (n = 166). HPV-positive OPC had a higher five-year OS (59.3%; n = 127) compared to HPV-negative (35.4%; n = 226). Multivariable analysis identified older age (≥ 70 years) and advanced TNM stage (IV) as adverse prognostic factors for oral cavity, oropharynx, and larynx sites. Male gender was associated with poorer prognosis in the oral cavity, while alcohol consumption was linked to worse outcomes in oropharynx and larynx sites.
HNSCC OS remains low at a public cancer center in São Paulo. Older age, advanced tumor stage, and alcohol consumption are independent adverse prognostic factors, particularly in oropharynx and larynx sites.
评估头颈部鳞状细胞癌（HNSCC）诊断时的社会人口统计学、临床和生活方式特征，以及它们对不同解剖部位总生存期（OS）的影响。
在圣保罗州癌症研究所进行的一项回顾性队列研究（2011 - 2021年），纳入3052例HNSCC患者。生存分析采用Kaplan - Meier法和Cox比例风险比，并给出95%置信区间，纳入单因素分析中的显著变量。
所有HNSCC部位（n = 3052）的五年总生存率为31.4%，其中喉癌（n = 935）为37.0%，口腔癌（n = 762）为35.8%，口咽癌（OPC）（n = 1189）为26.6%，下咽癌（n = 166）为14.8%。HPV阳性的OPC患者五年总生存率（59.3%；n = 127）高于HPV阴性患者（35.4%；n = 226）。多因素分析确定年龄较大（≥70岁）和TNM分期晚期（IV期）是口腔、口咽和喉部的不良预后因素。男性性别与口腔预后较差相关，而饮酒与口咽和喉部的较差结局相关。
在圣保罗的一家公立癌症中心，HNSCC的总生存率仍然较低。年龄较大、肿瘤分期较晚和饮酒是独立的不良预后因素，特别是在口咽和喉部。
