The effect of azelaic acid on AlCl-induced neurocognitive impairments and molecular changes in the hippocampus of rats.

OBJECTIVES

Cognitive function plays a pivotal role in assessing an individual's quality of life. This research aimed to investigate how azelaic acid (AzA), a natural dicarboxylic acid with antioxidant and anti-inflammatory properties, affects aluminium chloride (AlCl)-induced behavioural changes and biochemical alterations in the hippocampus of rats.

METHODS

Thirty-two male Wistar rats divided into four groups received distilled water, AzA 50 mg/kg, AlCl 100 mg/kg and AzA plus AlCl, respectively, by oral gavage for 6 weeks. Behavioural changes were evaluated using open-field maze, elevated plus maze, novel object recognition (NOR), passive avoidance task, and Morris water maze (MWM) tests. Also, malondialdehyde (MDA), carbonyl protein, tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), nuclear factor-kappa B (NF-κB), C/EBP homologous protein (CHOP), glycogen synthase kinase-3 beta (GSK-3β), brain-derived neurotrophic factor (BDNF) and acetylcholinesterase (AChE) activity were examined.

RESULTS

AzA significantly affected AlCl-provoked anxiety-like behaviours and learning and memory impairments. It also reduced the toxic effect of AlCl on MDA, carbonyl protein, TNF-α, IL-1β, NF-κB and GSK-3β status; however, its beneficial effects on AlCl-induced changes of CHOP, BDNF and AChE activity were not significant.

CONCLUSION

These findings disclosed that AzA could improve behavioural and cognitive function and almost limit the oxidative stress and neuroinflammation caused by AlCl.