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新辅助化疗后cN+乳腺癌患者的腋窝淋巴结管理策略

Axillary lymph node management strategies in cN + breast cancer patients after neoadjuvant chemotherapy.

作者信息

Gao Min, Chen Xiaoxi, Xu Ling

机构信息

Breast Disease Center, Peking University First Hospital, Beijing, 100034, China.

出版信息

Clin Transl Oncol. 2024 Dec 17. doi: 10.1007/s12094-024-03817-6.

Abstract

With the widespread use of neoadjuvant chemotherapy (NAC), the optimal management strategy for axillary lymph nodes following chemotherapy has become a hot topic of discussion. For patients with clinically positive axillary lymph nodes (cN +) (defined as axillary lymph nodes confirmed positive by pathology before NAC), axillary lymph node dissection (ALND) remains the current standard treatment. However, there is still no consensus on whether sentinel lymph node biopsy (SLNB) and other local axillary treatments following NAC can safely replace ALND to reduce injury and complications. This article provides a narrative review of strategies for managing axillary lymph nodes in this patient population.

摘要

随着新辅助化疗(NAC)的广泛应用,化疗后腋窝淋巴结的最佳管理策略已成为讨论的热点话题。对于临床腋窝淋巴结阳性(cN +)(定义为新辅助化疗前经病理证实腋窝淋巴结阳性)的患者,腋窝淋巴结清扫术(ALND)仍然是当前的标准治疗方法。然而,关于前哨淋巴结活检(SLNB)和新辅助化疗后的其他腋窝局部治疗能否安全替代腋窝淋巴结清扫术以减少损伤和并发症,目前仍未达成共识。本文对该患者群体腋窝淋巴结管理策略进行了叙述性综述。

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