Li Xin, Huang Bo, Liu Yue, Wang Meng, Cui Jing-Qiu
Tianjin Medical University General Hospital, People's Republic of China.
Tianjin Medical University General Hospital, People's Republic of China.
J Diabetes Complications. 2025 Feb;39(2):108929. doi: 10.1016/j.jdiacomp.2024.108929. Epub 2024 Dec 5.
Uric acid (UA) is mainly synthesized in the liver, intestine, and vascular endothelium and excreted by the kidney (70 %) and intestine (30 %). Hyperuricemia (HUA) occurs when UA production exceeds excretion. Many studies have found that elevated UA is associated with diabetic microvascular complications (DMC), including diabetic retinopathy (DR), diabetic nephropathy (DN), and diabetic peripheral neuropathy (DPN). In addition, too high or too low UA levels will promote the occurrence and development of chronic diseases, but the relationship between UA and diabetic microvascular complications (DMC) is not clear. Therefore, the rational treatment of UA in patients with diabetes is essential. In this review, we summarize and discuss the mechanism and treatment of UA and DMC and may provide potential advice for rational drug selection.
尿酸（UA）主要在肝脏、肠道和血管内皮中合成，并通过肾脏（70%）和肠道（30%）排泄。当尿酸生成超过排泄时，就会发生高尿酸血症（HUA）。许多研究发现，尿酸升高与糖尿病微血管并发症（DMC）有关，包括糖尿病视网膜病变（DR）、糖尿病肾病（DN）和糖尿病周围神经病变（DPN）。此外，尿酸水平过高或过低都会促进慢性病的发生和发展，但尿酸与糖尿病微血管并发症（DMC）之间的关系尚不清楚。因此，合理治疗糖尿病患者的尿酸至关重要。在这篇综述中，我们总结并讨论了尿酸与糖尿病微血管并发症的机制及治疗方法，可能为合理用药提供潜在建议。
