Junier Marie-Pierre, El-Habr Elias A
Sorbonne université, CNRS, INSERM, Institut de Biologie Paris Seine, F-75005 Paris, France.
Sorbonne université, CNRS, INSERM, Institut de Biologie Paris Seine, F-75005 Paris, France.
Dev Cell. 2024 Dec 16;59(24):3189-3190. doi: 10.1016/j.devcel.2024.11.012.
Glioblastoma cells exhibit remarkable plasticity, enabling them to adapt to environmental cues and transition through various developmental-like states with distinct properties. In this issue of Developmental Cell, Loftus et al. identify ILK as an intrinsic regulator of glioblastoma cell transitions between progenitor-like and mesenchymal/astrocyte-like states.
胶质母细胞瘤细胞表现出显著的可塑性，使它们能够适应环境线索，并通过具有不同特性的各种类似发育的状态进行转变。在本期《发育细胞》中，洛夫特斯等人确定整合素连接激酶（ILK）是胶质母细胞瘤细胞在祖细胞样状态和间充质/星形胶质细胞样状态之间转变的内在调节因子。
