Davoudi Zahra, Bikdeli Pegah, Oshidari Bahador, Erfanifar Azam, Kazempour Muhanna, Jolfaei Pardis, Toreyhi Hossein, Mirhashemi Seyedhadi
Department of Endocrinology, Research Center of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of internal medicine, Research Center of Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Obes Surg. 2025 Jan;35(1):189-197. doi: 10.1007/s11695-024-07617-3. Epub 2024 Dec 17.
Obesity is a prevalent metabolic disorder that significantly contributes to insulin resistance (IR), type 2 diabetes (T2DM), and metabolic syndrome. Sleeve gastrectomy has emerged as an effective surgical intervention for obesity, with potential benefits on metabolic health. This study investigates the impact of sleeve gastrectomy on serum insulin levels, IR (HOMA-IR), inflammatory markers, C-peptide, kidney function, and various biochemical parameters in diabetic and non-diabetic patients.
A prospective cohort study was conducted, involving 199 patients over 18 years old who were candidates for sleeve gastrectomy at Luqman Hakim Hospital from 2021 to 2022. Data were collected using standardized questionnaires and anthropometric measurements, and biochemical assessments were performed before surgery and 6 months postoperatively. Statistical analyses included descriptive statistics, t-tests, Mann-Whitney tests, and repeated measures analysis of variances (ANOVA).
The study included 199 patients (84.4% female) with a mean (± standard deviation (SD)) age of 39.79 ± 11.30 years. Significant reductions were observed in weight, BMI, and abdominal circumference across all patient groups. Diabetic patients showed marked improvements in fasting blood sugar, 2-h postprandial blood sugar, and glycosylated hemoglobin levels. Insulin resistance decreased significantly, as did serum insulin and C-peptide levels. Improvements in lipid profiles and inflammatory markers were also noted. Insulin use post-surgery showed a significant inverse relationship with glycemic control improvement.
Sleeve gastrectomy is a safe and effective procedure for obese patients, significantly improving insulin resistance and various obesity-associated diseases within 6 months post-surgery.
肥胖是一种普遍存在的代谢紊乱疾病，对胰岛素抵抗（IR）、2型糖尿病（T2DM）和代谢综合征有显著影响。袖状胃切除术已成为治疗肥胖的一种有效手术干预方式，对代谢健康具有潜在益处。本研究调查了袖状胃切除术对糖尿病和非糖尿病患者血清胰岛素水平、IR（稳态模型评估胰岛素抵抗指数）、炎症标志物、C肽、肾功能及各种生化参数的影响。
进行了一项前瞻性队列研究，纳入了199例年龄超过18岁的患者，这些患者均为2021年至2022年在鲁克曼·哈基姆医院接受袖状胃切除术的候选者。通过标准化问卷和人体测量收集数据，并在手术前和术后6个月进行生化评估。统计分析包括描述性统计、t检验、曼-惠特尼检验和重复测量方差分析（ANOVA）。
该研究纳入了199例患者（84.4%为女性），平均（±标准差）年龄为39.79±11.30岁。所有患者组的体重、体重指数（BMI）和腹围均显著降低。糖尿病患者的空腹血糖、餐后2小时血糖和糖化血红蛋白水平有明显改善。胰岛素抵抗显著降低，血清胰岛素和C肽水平也降低。血脂谱和炎症标志物也有所改善。术后胰岛素使用情况与血糖控制改善呈显著负相关。
袖状胃切除术对肥胖患者是一种安全有效的手术，在术后6个月内可显著改善胰岛素抵抗和各种肥胖相关疾病。
