Domínguez Alvarado Gonzalo A, Otero Rosales María C, Cala Duran Julián C, Serrano-Gómez Sergio, Carrero Barragan Tania Y, Domínguez Alvarado Paula N, Ramírez Martha L, Serrano-Mesa Kamila, Lozada-Martinez Ivan D, Narvaez-Rojas Alexis R, López Gómez Luis E
Grupo de Innovación e Investigación Quirúrgica, School of Medicine Universidad Autónoma de Bucaramanga Bucaramanga Colombia.
School of Medicine Universidad Industrial de Santander Bucaramanga Colombia.
Health Sci Rep. 2023 Jan 30;6(2):e1090. doi: 10.1002/hsr2.1090. eCollection 2023 Feb.
Metabolic syndrome (MetS) represents a group of metabolic abnormalities. It is currently a pandemic, and its prevalence is on the rise. MetS has a direct relationship with obesity, for this reason, bariatric and metabolic surgery has been proposed as a method to simultaneously control obesity and MetS. However, in Colombia the results of this intervention are unknown. This study aims to compare metabolic syndrome before and after bariatric surgery in a Colombian population.
Retrospective cohort study conducted in a highly complex institution in Colombia, where comparing the prevalence of metabolic syndrome in patients who underwent bariatric surgery during a 1-year follow-up period, between January 2015 and December 2019. Of these patients, 48 underwent Roux-en-Y gastric bypass, and 32 underwent sleeve gastrectomy by laparoscopic technique.
A total of 80 patients were included, of which 67.5% were women and the mean age was 42.8 ± 12.9 years. The most frequent preprocedure comorbidities were arterial hypertension (36.2%), dyslipidemia (32.4%), and sleep apnea (20%). After bariatric surgery, the prevalence of metabolic syndrome decreased from 66.2% to 3.7% ( < 0.05). In addition, a reduction in the Homeostatic Model Assessment for Insulin Resistance score from 77.5% to 22.5% was observed during the follow-up period. HbA1c, creatinine, and thyroid-stimulating hormone, were the only parameters without significant changes.
Metabolic and bariatric surgery is an effective treatment for weight reduction, with a high impact in reducing the prevalence of metabolic syndrome and insulin resistance in the short and medium term in the Colombian population.
代谢综合征（MetS）是一组代谢异常情况。它目前呈全球流行趋势，且患病率不断上升。MetS与肥胖有直接关系，因此，减重代谢手术已被提议作为一种同时控制肥胖和MetS的方法。然而，在哥伦比亚，这种干预措施的效果尚不清楚。本研究旨在比较哥伦比亚人群减重手术后代谢综合征的变化情况。
在哥伦比亚一家高度复杂的机构进行回顾性队列研究，比较2015年1月至2019年12月期间接受减重手术患者在1年随访期内代谢综合征的患病率。其中，48例行Roux-en-Y胃旁路手术，32例行腹腔镜袖状胃切除术。
共纳入80例患者，其中67.5%为女性，平均年龄为42.8±12.9岁。术前最常见的合并症是动脉高血压（36.2%）、血脂异常（32.4%）和睡眠呼吸暂停（20%）。减重手术后，代谢综合征的患病率从66.2%降至3.7%（P<0.05）。此外，随访期间胰岛素抵抗稳态模型评估得分从77.5%降至22.5%。糖化血红蛋白、肌酐和促甲状腺激素是仅有的无显著变化的参数。
减重代谢手术是一种有效的减重治疗方法，对降低哥伦比亚人群中代谢综合征和胰岛素抵抗的患病率在短期和中期有很大影响。
