二氧化钛催化活性亚甲基化合物与重氮盐的直接重氮基化反应
TiO-Catalyzed Direct Diazenylation of Active Methylene Compounds with Diazonium Salts.
作者信息
Evangelista Edson, de Carvalho Yuri P V, de Jesus Iva S, Rodrigues Maria Eduarda S, Hayashi Emelli P, de Andrade Karine N, Fiorot Rodolfo G, da S M Forezi Luana
机构信息
Department of Organic Chemistry, Institute of Chemistry, Federal Fluminense University─UFF, Niteroi, Rio de Janeiro 24020-141, Brazil.
Department of Pharmaceutical Technology, Federal Fluminense University─UFF, Niteroi, Rio de Janeiro 24241-000, Brazil.
出版信息
J Org Chem. 2025 Jan 10;90(1):300-308. doi: 10.1021/acs.joc.4c02266. Epub 2024 Dec 17.
Herein, we report a direct diazenylation of active methylene compounds that is environmentally friendly, cost-effective, and scalable, utilizing a heterogeneous TiO catalyst that is both accessible and recyclable. The scope of this transformation shows excellent compatibility with both electron-rich and electron-poor diazonium salts, yielding the desired products in very good yields at room temperature.
在此，我们报道了一种活性亚甲基化合物的直接重氮基化反应，该反应环境友好、成本效益高且可扩展，使用了一种易于获得且可回收的多相TiO催化剂。这种转化的范围显示出与富电子和贫电子重氮盐都具有出色的兼容性，在室温下以非常好的产率得到所需产物。
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