Artigou Hélène, Foka Tichoue Hervé, Marques Cindy, Charlotte Frédéric, Vion P A, Kas Aurélie, Rozenblum Laura
From the Department of Nuclear Medicine, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
University Cancer Institut, Sorbonne University, Department of Medical Oncology, Pitié-Salpétrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Clin Nucl Med. 2025 Feb 1;50(2):e92-e93. doi: 10.1097/RLU.0000000000005580. Epub 2024 Dec 18.
In oncology, G-CSF (granulocyte colony-stimulating factor) is often administered to counteract chemotherapy-induced neutropenia. Recent studies have highlighted a significant side effect, G-CSF-associated aortitis, with an incidence of ~0.4%. Identification of this condition's imaging characteristics is crucial for nuclear medicine specialists, given its substantial impact on clinical decision-making. It is notably prevalent in the follow-up of gynecologic malignancies and lymphoma. We detail a case of G-CSF-related aortitis in a metastatic ovarian cancer patient, diagnosed by increased 18 F-FDG uptake in the aortic arch on PET/CT, confirmed by contrast-enhanced CT and biopsy, which regressed spontaneously in under 5 weeks without corticosteroid treatment.
在肿瘤学中，经常使用粒细胞集落刺激因子（G-CSF）来对抗化疗引起的中性粒细胞减少。最近的研究突出了一个显著的副作用，即G-CSF相关性主动脉炎，发病率约为0.4%。鉴于这种情况对临床决策有重大影响，识别其影像学特征对核医学专家至关重要。它在妇科恶性肿瘤和淋巴瘤的随访中尤为普遍。我们详细介绍了一例转移性卵巢癌患者发生的G-CSF相关性主动脉炎病例，通过PET/CT上主动脉弓18F-FDG摄取增加得以诊断，经增强CT和活检证实，在未进行皮质类固醇治疗的情况下，5周内自行消退。
