Nanda Civilee, Sachdev Namrita
Department of Radiodiagnosis, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Neurol India. 2024 Nov 1;72(6):1169-1173. doi: 10.4103/ni.ni_894_22. Epub 2024 Dec 17.
Vascular hypotheses was previously considered to play a major role in pathophysiology of migraine. Recently, neurological mechanisms have been proposed with implication of the trigemino-vascular pathway. Deciphering the pathophysiology of this disorder is extremely important for diagnosis, assessment of progression and to explore targeted treatment options.
To assess white matter alterations in patients of migraine by using Diffusion Tensor Imaging.
We performed Diffusion Tensor Imaging in migraine patients to assess changes in microstructural integrity of white matter tracts involved in pain processing to localize the tracts involved in migraine. This is a cross-sectional observational study involving 50 subjects (30 patients of migraine diagnosed as per ICHD-III and 20 age and sex matched controls). DTI was performed on 3T MRI and the mean diffusivity and fractional anisotropy values of the cases were compared with controls.
Significant changes were noted in the multiple white matter tracts implicated in pain processing compared to the controls. Significant association was also noted between the DTI parameters and the type and frequency of migraine. DTI can thus assist in the diagnosis, assessing the extent of neurological damage in patients of migraine and follow up post treatment.
血管假说曾被认为在偏头痛的病理生理学中起主要作用。最近，有研究提出了涉及三叉神经血管通路的神经机制。解读这种疾病的病理生理学对于诊断、病情进展评估以及探索靶向治疗方案极为重要。
通过扩散张量成像评估偏头痛患者的白质改变。
我们对偏头痛患者进行了扩散张量成像，以评估参与疼痛处理的白质束微观结构完整性的变化，从而确定与偏头痛相关的白质束。这是一项横断面观察性研究，涉及50名受试者（30名根据国际头痛疾病分类第三版（ICHD-III）诊断的偏头痛患者和20名年龄及性别匹配的对照者）。在3T磁共振成像上进行扩散张量成像，并将病例的平均扩散率和分数各向异性值与对照组进行比较。
与对照组相比，在多个参与疼痛处理的白质束中发现了显著变化。扩散张量成像参数与偏头痛的类型和频率之间也存在显著关联。因此，扩散张量成像有助于偏头痛的诊断、评估患者神经损伤的程度以及治疗后的随访。
