Zhang Lei, Gong Yi-Miao, Wang San-Wang, Shi Pei-Ling, Li Ming-Zhe, Wen Xin, Wang Di-Xin, Zheng Yong-Bo, Han Yong
Department of Nutrition,Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, China.
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Chinese Academy of Medical Sciences Research Unit (No. 2018RU006), Peking University, Beijing, China.
Front Aging Neurosci. 2024 Dec 3;16:1422862. doi: 10.3389/fnagi.2024.1422862. eCollection 2024.
Posttraumatic stress disorder (PTSD) is associated with the development of dementia. However, the link between PTSD and preclinical Alzheimer's disease pathology (amyloid [Aβ]) remains controversial. Moreover, the correlation between the severity of PTSD with Aβ levels remains unknown.
This cross-sectional study sought to investigate the associations of PTSD symptoms with global and regional brain Aβ burden. To this end, data were obtained from participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Study. In addition, we explored the association between the severity of PTSD symptoms and Aβ levels.
A total of 4,228 participants aged 65 to 85 years were included in the final analysis. The results showed that PTSD symptoms were significantly associated with higher global Aβ levels (1.15 ± 0.20 vs. 1.09 ± 0.19; β = 0.056; < 0.001), after adjusting for covariates. The association between PTSD symptoms and Aβ levels was not affected by sex, age, genotype, or psychiatric diseases. Similarly, PTSD symptoms were significantly associated with Aβ levels in all subregions, including the anterior cingulate, posterior cingulate, parietal cortex, precuneus, temporal cortex, and frontal cortex. In addition, the group with severe PTSD symptoms (1.22 ± 0.24) exhibited higher global Aβ levels than the groups with moderate (1.14 ± 0.19) or mild (1.12 ± 0.20) symptoms or the control (1.08 ± 0.18), with < 0.001.
The findings imply a close relationship between PTSD and brain Aβ levels, irrespective of sex, age, genotype, or psychiatric diseases. More well-designed studies are needed to further explore the relationship and mechanism underlying the association between PTSD and Aβ burden.
创伤后应激障碍（PTSD）与痴呆症的发生有关。然而，PTSD与临床前阿尔茨海默病病理（淀粉样蛋白[Aβ]）之间的联系仍存在争议。此外，PTSD严重程度与Aβ水平之间的相关性尚不清楚。
这项横断面研究旨在调查PTSD症状与全脑及区域脑Aβ负担之间的关联。为此，数据来自无症状阿尔茨海默病抗淀粉样蛋白治疗（A4）研究的参与者。此外，我们还探讨了PTSD症状严重程度与Aβ水平之间的关联。
最终分析纳入了4228名年龄在65至85岁之间的参与者。结果显示，在调整协变量后，PTSD症状与更高的全脑Aβ水平显著相关（1.15±0.20 vs. 1.09±0.19；β=0.056；<0.001）。PTSD症状与Aβ水平之间的关联不受性别、年龄、基因型或精神疾病的影响。同样，PTSD症状与所有亚区域的Aβ水平均显著相关，包括前扣带回、后扣带回、顶叶皮质、楔前叶、颞叶皮质和额叶皮质。此外，重度PTSD症状组（1.22±0.24）的全脑Aβ水平高于中度（1.14±0.19）或轻度（1.12±0.20）症状组或对照组（1.08±0.18），<0.001。
研究结果表明，无论性别、年龄、基因型或精神疾病如何，PTSD与脑Aβ水平之间都存在密切关系。需要更多设计良好的研究来进一步探索PTSD与Aβ负担之间关联的关系及潜在机制。
