Sun Jiaqi, Song Jiahao
Department of Cardiology, The Second Affiliated Hospital of Xinjiang Medical University Urumqi City 830000 China
RSC Adv. 2024 Dec 17;14(53):39636-39644. doi: 10.1039/d4ra07857h. eCollection 2024 Dec 10.
Chromeno[4,3-]chromenes have shown potential as effective drugs against cardiovascular diseases. This study centered on a novel heterojunction nanocomposite TiO/CuWO, which incorporates titanium dioxide (TiO) and copper tungstate(vi) to improve photocatalytic efficiency. The characterization of the TiO/CuWO photocatalyst was performed using various techniques, including FT-IR, XRD, TEM, DRS, SEM, EDS, and XPS. TiO/CuWO demonstrated significant effectiveness as a photocatalyst for the synthesis of chromeno[4,3-]chromene derivatives, which show potential antibacterial and antifungal properties beneficial for oral health concerns such as dental caries and periodontal disease. While TiO can absorb light to produce electrons and holes under direct illumination, its photocatalytic efficiency is improved when paired with CuWO. The research also explored the influence of several factors, including the quantity of photocatalyst, reaction duration, temperature, solvent selection, and the reusability of the nanocomposite. Optimal reaction conditions were found to involve 1 mmol of dimedone, benzaldehyde, and 4-hydroxycoumarin, using 12 mg of TiO/CuWO in 4 mL of ethanol, subjected to irradiation from a green laser at room temperature for 30 minutes. The results indicate that the TiO/CuWO heterojunction ranks among the most effective options for photocatalytic synthesis of chromeno[4,3-]chromene derivatives.
色烯并[4,3 - ]色烯已显示出作为抗心血管疾病有效药物的潜力。本研究聚焦于一种新型异质结纳米复合材料TiO/CuWO₄，它结合了二氧化钛（TiO₂）和钨酸铜（CuWO₄）以提高光催化效率。使用包括傅里叶变换红外光谱（FT - IR）、X射线衍射（XRD）、透射电子显微镜（TEM）、漫反射光谱（DRS）、扫描电子显微镜（SEM）、能谱分析（EDS）和X射线光电子能谱（XPS）等各种技术对TiO/CuWO₄光催化剂进行了表征。TiO/CuWO₄作为合成色烯并[4,3 - ]色烯衍生物的光催化剂显示出显著效果，这些衍生物具有潜在的抗菌和抗真菌特性，对诸如龋齿和牙周病等口腔健康问题有益。虽然TiO₂在直接光照下能吸收光产生电子和空穴，但与CuWO₄配对时其光催化效率会提高。该研究还探讨了几个因素的影响，包括光催化剂的用量、反应持续时间、温度、溶剂选择以及纳米复合材料的可重复使用性。发现最佳反应条件为使用1 mmol的达米酮、苯甲醛和4 - 羟基香豆素，并在4 mL乙醇中使用12 mg的TiO/CuWO₄，在室温下用绿色激光照射30分钟。结果表明，TiO/CuWO₄异质结是光催化合成色烯并[4,3 - ]色烯衍生物最有效的选择之一。
