Teymouri Farzad, Sebastian Gale, Gem Hakan, Minot Samuel S, Rashidi Armin
Department of Internal Medicine Eisenhower Health Rancho Mirage California USA.
Department of Oral Medicine University of Washington and Fred Hutchinson Cancer Center Seattle Washington USA.
EJHaem. 2024 Oct 20;5(6):1290-1294. doi: 10.1002/jha2.1033. eCollection 2024 Dec.
Oral acute graft-versus-host disease (aGVHD) is rare and with no diagnostic criteria. We report a case of oral aGVHD with three clinical phases. A self-limited prodrome of largely subjective oral symptoms was followed by concurrent oral and upper gastrointestinal aGVHD. Six months after transplantation, the patient was diagnosed with severe oral and upper gastrointestinal chronic GVHD. We compared the salivary microbiota of our patient at the time of diagnosis of aGVHD with 50 contemporaneous transplant recipients and found no evidence for oral microbiota involvement in pathogenesis. This in-depth N-of-1 analysis reveals novel aspects of oral aGVHD pathogenesis.
口腔急性移植物抗宿主病（aGVHD）较为罕见，且尚无诊断标准。我们报告一例具有三个临床阶段的口腔aGVHD病例。先是出现以主观口腔症状为主的自限性前驱症状，随后并发口腔和上消化道aGVHD。移植后6个月，该患者被诊断为严重的口腔和上消化道慢性移植物抗宿主病（GVHD）。我们将该患者在aGVHD诊断时的唾液微生物群与50名同期移植受者进行了比较，未发现口腔微生物群参与发病机制的证据。这种深入的单病例分析揭示了口腔aGVHD发病机制的新方面。
