Casitas B细胞淋巴瘤b（CBL-B）选择性抑制剂在癌症免疫治疗中的潜在治疗益处。
Potential Therapeutic Benefit of the Selective Inhibitors of Casitas B Cell Lymphoma-b (CBL-B) in Cancer Immunotherapy.
作者信息
Abdel-Magid Ahmed F
机构信息
PI Health Sciences, 100 Jade Park, Chelsea, Alabama 35043, United State.
出版信息
ACS Med Chem Lett. 2024 Nov 19;15(12):2085-2087. doi: 10.1021/acsmedchemlett.4c00533. eCollection 2024 Dec 12.
Abstract
The invention in this patent application relates to 1,6-dihydro-7-pyrrolo[2,3-]pyridin-7-one derivatives represented generally by formula 1. These compounds are inhibitors of the E3 ubiquitin ligase, casitas B-lineage lymphoma proto-oncogene-b (CBL-B), and may be useful for the treatment of immunosuppression-associated diseases and disorders such as cancer and chronic viral infections.
摘要
本专利申请中的发明涉及通式1所示的1,6 - 二氢 - 7 - 吡咯并[2,3 - ]吡啶 - 7 - 酮衍生物。这些化合物是E3泛素连接酶——卡斯他B系淋巴瘤原癌基因b（CBL - B）的抑制剂，可用于治疗与免疫抑制相关的疾病和病症，如癌症和慢性病毒感染。
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本文引用的文献
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Casitas b cell lymphoma‑B (Cbl-b): A new therapeutic avenue for small-molecule immunotherapy.卡斯蒂亚斯 B 细胞淋巴瘤-B（Cbl-b）：小分子免疫治疗的新途径。
Bioorg Med Chem. 2024 Mar 15;102:117677. doi: 10.1016/j.bmc.2024.117677. Epub 2024 Mar 6.
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Rising Star in Immunotherapy: Development and Therapeutic Potential of Small-Molecule Inhibitors Targeting Casitas B Cell Lymphoma-b (Cbl-b).免疫疗法的新星：靶向 Casitas B 细胞淋巴瘤-b（Cbl-b）的小分子抑制剂的开发和治疗潜力。
J Med Chem. 2024 Jan 25;67(2):816-837. doi: 10.1021/acs.jmedchem.3c01361. Epub 2024 Jan 5.
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Targeting Cbl-b in cancer immunotherapy.靶向 Cbl-b 进行癌症免疫治疗。
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Regulation of immune responses by E3 ubiquitin ligase Cbl-b.E3 泛素连接酶 Cbl-b 对免疫反应的调节。
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Essential role of E3 ubiquitin ligase activity in Cbl-b-regulated T cell functions.E3泛素连接酶活性在Cbl-b调节的T细胞功能中的重要作用。
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